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CDC45_SCHPO
ID   CDC45_SCHPO             Reviewed;         638 AA.
AC   O74113;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Cell division control protein 45 homolog;
DE   AltName: Full=Suppressor of nda4 protein;
GN   Name=sna41; ORFNames=SPAC17D4.02;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=9619628; DOI=10.1046/j.1365-2443.1998.00177.x;
RA   Miyake S., Yamashita S.;
RT   "Identification of sna41 gene, which is the suppressor of nda4 mutation and
RT   is involved in DNA replication in Schizosaccharomyces pombe.";
RL   Genes Cells 3:157-166(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   INTERACTION WITH SLD3.
RX   PubMed=12006645; DOI=10.1091/mbc.02-01-0006;
RA   Nakajima R., Masukata H.;
RT   "SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in
RT   DNA replication in fission yeast.";
RL   Mol. Biol. Cell 13:1462-1472(2002).
CC   -!- FUNCTION: Required for initiation of chromosomal DNA replication. May
CC       have a role in regulating the MCM proteins nda1 and nda4.
CC       {ECO:0000269|PubMed:9619628}.
CC   -!- SUBUNIT: Interacts with sld3. {ECO:0000269|PubMed:12006645}.
CC   -!- INTERACTION:
CC       O74113; Q09761: sld3; NbExp=2; IntAct=EBI-1559427, EBI-1559416;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9619628}.
CC   -!- SIMILARITY: Belongs to the CDC45 family. {ECO:0000305}.
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DR   EMBL; AB001739; BAA28947.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAC05732.1; -; Genomic_DNA.
DR   PIR; T43018; T43018.
DR   RefSeq; NP_594693.1; NM_001020121.2.
DR   AlphaFoldDB; O74113; -.
DR   SMR; O74113; -.
DR   BioGRID; 278735; 23.
DR   IntAct; O74113; 3.
DR   MINT; O74113; -.
DR   STRING; 4896.SPAC17D4.02.1; -.
DR   iPTMnet; O74113; -.
DR   MaxQB; O74113; -.
DR   PaxDb; O74113; -.
DR   PRIDE; O74113; -.
DR   EnsemblFungi; SPAC17D4.02.1; SPAC17D4.02.1:pep; SPAC17D4.02.
DR   GeneID; 2542266; -.
DR   KEGG; spo:SPAC17D4.02; -.
DR   PomBase; SPAC17D4.02; -.
DR   VEuPathDB; FungiDB:SPAC17D4.02; -.
DR   eggNOG; KOG2475; Eukaryota.
DR   HOGENOM; CLU_005871_3_0_1; -.
DR   InParanoid; O74113; -.
DR   OMA; PWNLANV; -.
DR   PhylomeDB; O74113; -.
DR   Reactome; R-SPO-176187; Activation of ATR in response to replication stress.
DR   Reactome; R-SPO-68962; Activation of the pre-replicative complex.
DR   PRO; PR:O74113; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IDA:PomBase.
DR   GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0003682; F:chromatin binding; IDA:PomBase.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:1902975; P:mitotic DNA replication initiation; IC:PomBase.
DR   GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IMP:PomBase.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IMP:PomBase.
DR   InterPro; IPR003874; CDC45.
DR   PANTHER; PTHR10507; PTHR10507; 1.
DR   Pfam; PF02724; CDC45; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..638
FT                   /note="Cell division control protein 45 homolog"
FT                   /id="PRO_0000192818"
FT   REGION          151..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  73379 MW;  AE537DE856AF61B7 CRC64;
     MFIKRSDYAS AYLKIKEASV SGGCTVQLFV ALDPDALCAC KLLSTLLKGD FISHKIRPVS
     GYRDLEQANK TLLEQNEDIK FIILLNCGTM VDLNNYLVSM EDVSIYVIDS HRPHNLNNIY
     IENNIFVFDD GDIEEDMNKI HDAWYAFNSH ELSDEENSDS SNEREEEVED DNRSVESYSS
     SDYQARSRRR FSEETTQRRA EIKEKRKKRK EFASILSEYY EKGSWYGESI TNILFAVASM
     LGREDNDMLW LAIVGLTCLE IHCQSSKKYF NRSYSLLKDE VNRLNPSPLE NQIVGRAHGK
     TPHDQSIRLE DEFRFMLVRH WSLYDSMLHS AYVGSRLHIW SEEGRKRLHK LLAKMGLSLV
     ECKQTYIHMN MDLKKTLKSS LKRFAPFYGL DDVIFHSFTR TYGFKCTLSA SDVSYAISAL
     LEMGNTGVLL QSKTVARSPD MTEEEYLEKF ENAQNQEWLH NFYDAYDALD DVDSLERALK
     LAMHLQRAIV RTGITLLEKR AIKTLRSFRF GLINEGPDLK IFMHPLALTK MSLWIAEAIN
     EQEREFGKLR HLPLVLAAFV EEKNRYLIVG TSTSAFTSNE DDDDDDGHGH NRFGVAFQEV
     ANMTSATLQM DCFEASVIEC QKSDLGVFLE SLSFKTLL
 
 
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