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CDC48_SOYBN
ID   CDC48_SOYBN             Reviewed;         807 AA.
AC   P54774;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Cell division cycle protein 48 homolog;
DE   AltName: Full=Valosin-containing protein homolog;
DE            Short=VCP;
GN   Name=CDC48;
OS   Glycine max (Soybean) (Glycine hispida).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC   Glycine subgen. Soja.
OX   NCBI_TaxID=3847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Williams 82; TISSUE=Etiolated hypocotyl;
RX   PubMed=7753826; DOI=10.1073/pnas.92.10.4457;
RA   Shi J., Dixon R.A., Gonzales R.A., Kjellbom P., Bhattacharyya M.K.;
RT   "Identification of cDNA clones encoding valosin-containing protein and
RT   other plant plasma membrane-associated proteins by a general
RT   immunoscreening strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:4457-4461(1995).
CC   -!- FUNCTION: Probably functions in cell division and growth processes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; U20213; AAA80587.1; -; mRNA.
DR   PIR; T06409; T06409.
DR   RefSeq; NP_001235099.1; NM_001248170.1.
DR   AlphaFoldDB; P54774; -.
DR   SMR; P54774; -.
DR   STRING; 3847.GLYMA13G39830.1; -.
DR   PRIDE; P54774; -.
DR   ProMEX; P54774; -.
DR   EnsemblPlants; KRH22853; KRH22853; GLYMA_13G323600.
DR   GeneID; 547850; -.
DR   Gramene; KRH22853; KRH22853; GLYMA_13G323600.
DR   KEGG; gmx:547850; -.
DR   eggNOG; KOG0730; Eukaryota.
DR   HOGENOM; CLU_000688_12_3_1; -.
DR   InParanoid; P54774; -.
DR   OMA; YMMEYYR; -.
DR   OrthoDB; 194195at2759; -.
DR   Proteomes; UP000008827; Chromosome 13.
DR   Genevisible; P54774; GM.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR   GO; GO:0051228; P:mitotic spindle disassembly; IBA:GO_Central.
DR   GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR005938; AAA_ATPase_CDC48.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR004201; Cdc48_dom2.
DR   InterPro; IPR029067; CDC48_domain_2-like_sf.
DR   InterPro; IPR003338; CDC4_N-term_subdom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 2.
DR   Pfam; PF17862; AAA_lid_3; 2.
DR   Pfam; PF02933; CDC48_2; 1.
DR   Pfam; PF02359; CDC48_N; 1.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01072; CDC48_2; 1.
DR   SMART; SM01073; CDC48_N; 1.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF54585; SSF54585; 1.
DR   TIGRFAMs; TIGR01243; CDC48; 1.
DR   PROSITE; PS00674; AAA; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell cycle; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Repeat.
FT   CHAIN           1..807
FT                   /note="Cell division cycle protein 48 homolog"
FT                   /id="PRO_0000084585"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          771..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        771..793
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         249..256
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         522..529
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   807 AA;  89770 MW;  08916CBA9C2F1435 CRC64;
     MSQQGESSDP KSGKKDFSTA ILERKKSPNR LVVDEAVNDD NSVVTMHPQT MEKLQLFRGD
     TILIKGKKRK DTICIALADE NCEEPKIRMN KVVRSNLRVR LGDVVSVHQC PDVKYGKRVH
     ILPIDDTIEG VTGNLFDAFL KPYFLEAYRP VRKGDLFLVR GGMRSVEFKV VETDPGEYCV
     VAPDTEIFCE GEPLKREDEE RLDEVGYDDV GGVRKQMAQI RELVELPLRH PQLFKSIGVK
     PPKGILLYGP PGSGKTLIAR AVANETGAFF FCINGPEIMS KLAGESESNL RKAFEEAEKN
     APSIIFIDEI DSIAPKREKT HGEVERRIVS QLLTLMDGLK SRAHVIVIGA TNRPNSIDPA
     LRRFGRFDRE IDIGVPDEVG RLEVLRIHTK NMKLSDDVDL ERIAKDTHGY VGADLAALCT
     EAALQCIREK MDVIDLEDET IDAEVLNSMA VTNEHFQTAL GTSNPSALRE TVVEVPNVSW
     EDIGGLENVK RELQETVQYP VEHPEKFEKF GMSPSKGVLF YGPPGCGKTL LAKAIANECQ
     ANFISVKGPE LLTMWFGESE ANVREIFDKA RQSAPCVLFF DELDSIATQR GSSVGDAGGA
     ADRVLNQLLT EMDGMSAKKT VFIIGATNRP DIIDPALLRP GRLDQLIYIP LPDEDSRHQI
     FKACLRKSPI AKNVDLRALA RHTQGFSGAD ITEICQRACK YAIRENIEKD IERERKSREN
     PEAMDEDTVD DEVAEIKAAH FEESMKFARR SVSDADIRKY QAFAQTLQQS RGFGSEFRFP
     ESGDRTTTGS DPFAASAGGA DEDDLYS
 
 
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