CDC4_CANAX
ID CDC4_CANAX Reviewed; 684 AA.
AC P53699;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Cell division control protein 4;
GN Name=CDC4;
OS Candida albicans (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5476;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SGY126;
RA Shieh J.C., White A.M., Rosamond J.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is essential for initiation of DNA replication
CC and separation of the spindle pole bodies to form the poles of the
CC mitotic spindle. It also plays a role in bud development, fusion of
CC zygotic nuclei after conjugation and various aspects of sporulation.
CC Required for HTA1-HTB1 locus transcription activation (By similarity).
CC {ECO:0000250}.
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DR EMBL; X96763; CAA65538.1; -; Genomic_DNA.
DR AlphaFoldDB; P53699; -.
DR SMR; P53699; -.
DR VEuPathDB; FungiDB:CAWG_01518; -.
DR VEuPathDB; FungiDB:CR_01680C_A; -.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031740; Cdc4_D.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF16856; CDC4_D; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Mitosis; Repeat; Sporulation; WD repeat.
FT CHAIN 1..684
FT /note="Cell division control protein 4"
FT /id="PRO_0000050898"
FT DOMAIN 212..258
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 322..351
FT /note="WD 1"
FT REPEAT 363..391
FT /note="WD 2"
FT REPEAT 403..431
FT /note="WD 3"
FT REPEAT 442..468
FT /note="WD 4"
FT REPEAT 478..506
FT /note="WD 5"
FT REPEAT 519..549
FT /note="WD 6"
FT REPEAT 561..589
FT /note="WD 7"
FT REGION 1..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 76091 MW; 3DD65DB31293B107 CRC64;
MPSCDDTASS DTDCQSQVSS TAHLHSYRSN GLVEPPSKRR LTTTNETSLS SAGATTFQIE
SPGSISAITT NNSTTSAGDS NNSNSFSDQH SRHPRTPNAM NSPTHTPISD IEEDPIQQLP
LPSPSASPIQ SDTENEHVTT PDSLQGKANL DSIENVMSNE PTTQSELVDL VTKLSGFLSE
ANQNHLVFKL LQKTTRPTLS TFNNLINNSL KRDILSNVPF EVTMKILSYL DYKTLLSVAQ
VCKKWFDIIN NPDTWIKLLK RDKLITDDAV IKYELQYPDQ LLREWSTLPE INSAQVLYKK
RKIIVNRWMD PKFKPHRISV SGHGNKVVTC LQHDDEKVVT GVDDKCISIY STQTGQLMKV
LEGHEGGVWA LKYTGNTLVT GSTDRTVRVW NMKTGQCTHI FRGHTSTIRC LDIIHPAVIG
KNQDGEDIVF PEYPLLITGS RDHNIHVWKL PVVDDSQDYI ETFEGEFDNP YLIAVLSGHT
QSVRSISGYG NIIISGSYDS TVRVWDLLDD GHCTHVLQGH LDRVYSTAID FHSKTCFSGS
MDSNINVWNF ETGELKKVLV GHASLVGLLD LVDDVLVSAA ADATLRIWDA KTGELRSKLK
GHGAAITCFE HDGLRVVSGS EKMLKLWNVE KGTFARDLLS DVTGGIWQVR FDYKRCVAAV
QRIINEDEGE TFIEILDFSQ PLLQ