CDC5L_NEMVE
ID CDC5L_NEMVE Reviewed; 805 AA.
AC A7SD85;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Cell division cycle 5-related protein;
DE AltName: Full=Cdc5-like protein;
GN Name=cdc5l; ORFNames=v1g169217;
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6;
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: DNA-binding protein involved in cell cycle control. May act
CC as a transcription activator. Plays role in pre-mRNA splicing as core
CC component of precatalytic, catalytic and postcatalytic spliceosomal
CC complexes. May also play a role in the response to DNA damage (DDR).
CC {ECO:0000250|UniProtKB:Q99459}.
CC -!- SUBUNIT: Component of the precatalytic, catalytic and postcatalytic
CC spliceosome complexes. {ECO:0000250|UniProtKB:Q99459}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q99459}. Note=May shuttle between
CC cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q99459}.
CC -!- SIMILARITY: Belongs to the CEF1 family. {ECO:0000305}.
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DR EMBL; DS469628; EDO38320.1; -; Genomic_DNA.
DR RefSeq; XP_001630383.1; XM_001630333.1.
DR AlphaFoldDB; A7SD85; -.
DR BMRB; A7SD85; -.
DR SMR; A7SD85; -.
DR STRING; 45351.EDO38320; -.
DR EnsemblMetazoa; EDO38320; EDO38320; NEMVEDRAFT_v1g169217.
DR GeneID; 5509907; -.
DR KEGG; nve:5509907; -.
DR eggNOG; KOG0050; Eukaryota.
DR HOGENOM; CLU_009082_0_0_1; -.
DR InParanoid; A7SD85; -.
DR OMA; PFRTQRE; -.
DR OrthoDB; 975557at2759; -.
DR PhylomeDB; A7SD85; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR021786; Cdc5p/Cef1_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF11831; Myb_Cef; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 3: Inferred from homology;
KW Cell cycle; Coiled coil; Cytoplasm; DNA damage; DNA repair; DNA-binding;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW RNA-binding; Spliceosome.
FT CHAIN 1..805
FT /note="Cell division cycle 5-related protein"
FT /id="PRO_0000342370"
FT DOMAIN 1..58
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 59..108
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 31..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 82..104
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 108..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 142..193
FT /evidence="ECO:0000255"
FT COILED 511..542
FT /evidence="ECO:0000255"
FT COILED 678..804
FT /evidence="ECO:0000255"
FT COMPBIAS 108..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 91940 MW; C8296FFFEDDF4484 CRC64;
MPRIIIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW YEWLDPSIKK
TEWSREEDEK LLHLAKLMPT QWRTIAPLIG RTAAQCLERY EYLLDQAQAK EGDKDEGDDP
RKLRPGEIDP NPETKPARPD PIDMDEDELE MLSEARARLA NTQGKKAKRK AREKQLEEAR
RLAALQKRRE LRAAGIDIRK HRKKKRGVDY NAEIPFEKKP ASGFYDTSDE NLPDYQPDFK
RLRQDHLEGK MRDEIEQQER KKDKERMKKK KESDLPGAVM QINKMNNPDH VKKRSKLVLP
KPQISDGELE EIVKMGYASE VARASVENGG QASDALLSEY SVTPAINKAL RTPRTPAEQD
TVLQEAQNIL ALSNVDTPLK GGLNTPMHES DFQGVTPRQQ AIQTPNMLLS TPYRTPGEGS
GSTPRQGMTP RGAIGTPSQR SVRDKLNINP EDAVMEEYES ECAAKQQQSE AKEQLLAGLA
SLPAPSNDFE IVLPETPAEA SEEHKPMDFV EDAADIDERA LALRAKQEEL ERRRRSQAVQ
RELPRPSNVN TSVLRPTNVE PPLSALQMAE ELIKKEMIVM LRNDIINHPT SQQIESLTNK
KTRNAAQAVI TGNRAALERD PMENFTDEEL SSAKNLLRQE MDFVKSKMAH SDLPLEAYSK
VWEECYAQVL FLPSQQRYTR AAMASKKDRL ESLEKRLELN RYQMTEDAKK AAKIEKKLKV
LLGGYQTRAV GLTKQLSDLH EQLEQSQVEM TTFQALRNQE LQAIPKRLEA LKEDVQRQTE
REKQLQAQYS ELLYERDSLL SKLQI
