CDC61_AERPE
ID CDC61_AERPE Reviewed; 395 AA.
AC Q9YEV6;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=ORC1-type DNA replication protein 1 {ECO:0000255|HAMAP-Rule:MF_01407};
DE AltName: Full=ORC1;
GN Name=orc1; OrderedLocusNames=APE_0475.1;
OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS K1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Aeropyrum.
OX NCBI_TaxID=272557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 9-395 IN COMPLEX WITH DNA AND ATP,
RP FUNCTION, DNA-BINDING, AND DOMAIN.
RX PubMed=17761880; DOI=10.1126/science.1143664;
RA Gaudier M., Schuwirth B.S., Westcott S.L., Wigley D.B.;
RT "Structural basis of DNA replication origin recognition by an ORC
RT protein.";
RL Science 317:1213-1216(2007).
CC -!- FUNCTION: Involved in regulation of DNA replication (By similarity).
CC Binds DNA. {ECO:0000255|HAMAP-Rule:MF_01407,
CC ECO:0000269|PubMed:17761880}.
CC -!- DOMAIN: Contains an N-terminal AAA+ ATPase domain and a C-terminal
CC winged-helix (WH) domain. Domains are separated by a rigid linker.
CC {ECO:0000269|PubMed:17761880}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000002; BAA79440.2; -; Genomic_DNA.
DR PIR; D72743; D72743.
DR PDB; 2V1U; X-ray; 3.10 A; A=9-395.
DR PDBsum; 2V1U; -.
DR AlphaFoldDB; Q9YEV6; -.
DR SMR; Q9YEV6; -.
DR STRING; 272557.APE_0475.1; -.
DR DNASU; 1444658; -.
DR EnsemblBacteria; BAA79440; BAA79440; APE_0475.1.
DR KEGG; ape:APE_0475.1; -.
DR PATRIC; fig|272557.25.peg.363; -.
DR eggNOG; arCOG00467; Archaea.
DR OMA; DMLGIIN; -.
DR EvolutionaryTrace; Q9YEV6; -.
DR Proteomes; UP000002518; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02928; TIGR02928; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; DNA replication; DNA-binding;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..395
FT /note="ORC1-type DNA replication protein 1"
FT /id="PRO_0000150981"
FT BINDING 63..67
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407,
FT ECO:0000269|PubMed:17761880"
FT BINDING 209
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407,
FT ECO:0000269|PubMed:17761880"
FT BINDING 221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407,
FT ECO:0000269|PubMed:17761880"
FT STRAND 12..15
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 17..20
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 33..41
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 44..46
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 55..57
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 65..83
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 87..93
FT /evidence="ECO:0007829|PDB:2V1U"
FT TURN 94..96
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 100..111
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 122..133
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 138..145
FT /evidence="ECO:0007829|PDB:2V1U"
FT TURN 146..148
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 149..152
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 156..165
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 166..168
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 177..181
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 188..191
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 193..196
FT /evidence="ECO:0007829|PDB:2V1U"
FT TURN 197..200
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 201..203
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 211..225
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 235..244
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 245..247
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 250..266
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 274..294
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 298..310
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 311..314
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 319..332
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 340..352
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 355..362
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 364..366
FT /evidence="ECO:0007829|PDB:2V1U"
FT STRAND 368..374
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 378..387
FT /evidence="ECO:0007829|PDB:2V1U"
FT HELIX 391..394
FT /evidence="ECO:0007829|PDB:2V1U"
SQ SEQUENCE 395 AA; 44313 MW; 999C820FE499C145 CRC64;
MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE KPSNALLYGL
TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP YRVASAIAEA VGVRVPFTGL
SVGEVYERLV KRLSRLRGIY IIVLDEIDFL PKRPGGQDLL YRITRINQEL GDRVWVSLVG
ITNSLGFVEN LEPRVKSSLG EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA
ALAAREHGDA RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA
KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL DMLGIVKSRV
VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL