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CDC61_AERPE
ID   CDC61_AERPE             Reviewed;         395 AA.
AC   Q9YEV6;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=ORC1-type DNA replication protein 1 {ECO:0000255|HAMAP-Rule:MF_01407};
DE   AltName: Full=ORC1;
GN   Name=orc1; OrderedLocusNames=APE_0475.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 9-395 IN COMPLEX WITH DNA AND ATP,
RP   FUNCTION, DNA-BINDING, AND DOMAIN.
RX   PubMed=17761880; DOI=10.1126/science.1143664;
RA   Gaudier M., Schuwirth B.S., Westcott S.L., Wigley D.B.;
RT   "Structural basis of DNA replication origin recognition by an ORC
RT   protein.";
RL   Science 317:1213-1216(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication (By similarity).
CC       Binds DNA. {ECO:0000255|HAMAP-Rule:MF_01407,
CC       ECO:0000269|PubMed:17761880}.
CC   -!- DOMAIN: Contains an N-terminal AAA+ ATPase domain and a C-terminal
CC       winged-helix (WH) domain. Domains are separated by a rigid linker.
CC       {ECO:0000269|PubMed:17761880}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; BA000002; BAA79440.2; -; Genomic_DNA.
DR   PIR; D72743; D72743.
DR   PDB; 2V1U; X-ray; 3.10 A; A=9-395.
DR   PDBsum; 2V1U; -.
DR   AlphaFoldDB; Q9YEV6; -.
DR   SMR; Q9YEV6; -.
DR   STRING; 272557.APE_0475.1; -.
DR   DNASU; 1444658; -.
DR   EnsemblBacteria; BAA79440; BAA79440; APE_0475.1.
DR   KEGG; ape:APE_0475.1; -.
DR   PATRIC; fig|272557.25.peg.363; -.
DR   eggNOG; arCOG00467; Archaea.
DR   OMA; DMLGIIN; -.
DR   EvolutionaryTrace; Q9YEV6; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; DNA replication; DNA-binding;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..395
FT                   /note="ORC1-type DNA replication protein 1"
FT                   /id="PRO_0000150981"
FT   BINDING         63..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407,
FT                   ECO:0000269|PubMed:17761880"
FT   BINDING         209
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407,
FT                   ECO:0000269|PubMed:17761880"
FT   BINDING         221
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407,
FT                   ECO:0000269|PubMed:17761880"
FT   STRAND          12..15
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           17..20
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           33..41
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           44..46
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          55..57
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           65..83
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          87..93
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   TURN            94..96
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           100..111
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           122..133
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          138..145
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   TURN            146..148
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           149..152
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           156..165
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           166..168
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          177..181
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          188..191
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           193..196
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   TURN            197..200
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          201..203
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           211..225
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           235..244
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          245..247
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           250..266
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           274..294
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           298..310
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          311..314
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           319..332
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           340..352
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          355..362
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           364..366
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   STRAND          368..374
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           378..387
FT                   /evidence="ECO:0007829|PDB:2V1U"
FT   HELIX           391..394
FT                   /evidence="ECO:0007829|PDB:2V1U"
SQ   SEQUENCE   395 AA;  44313 MW;  999C820FE499C145 CRC64;
     MEEVFTAALE SKIFRKRWVL LPDYVPDVLP HREAELRRLA EVLAPALRGE KPSNALLYGL
     TGTGKTAVAR LVLRRLEARA SSLGVLVKPI YVNARHRETP YRVASAIAEA VGVRVPFTGL
     SVGEVYERLV KRLSRLRGIY IIVLDEIDFL PKRPGGQDLL YRITRINQEL GDRVWVSLVG
     ITNSLGFVEN LEPRVKSSLG EVELVFPPYT APQLRDILET RAEEAFNPGV LDPDVVPLCA
     ALAAREHGDA RRALDLLRVA GEIAERRREE RVRREHVYSA RAEIERDRVS EVVRTLPLHA
     KLVLLSIMML EDGGRPASTG EIYERYKELT STLGLEHVTL RRVSGIISEL DMLGIVKSRV
     VSRGRYGKTR EVSLDADRLA VENALSEDPF VARLL
 
 
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