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CDC61_HALSA
ID   CDC61_HALSA             Reviewed;         308 AA.
AC   Q9HHZ9;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=ORC1-type DNA replication protein 1;
GN   Name=orc1; OrderedLocusNames=VNG_6150G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC200.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1; PLASMID=pNRC200;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000305}.
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DR   EMBL; AE004438; AAG20823.1; -; Genomic_DNA.
DR   RefSeq; WP_010904037.1; NZ_BK010831.1.
DR   AlphaFoldDB; Q9HHZ9; -.
DR   SMR; Q9HHZ9; -.
DR   EnsemblBacteria; AAG20823; AAG20823; VNG_6150G.
DR   GeneID; 5954695; -.
DR   GeneID; 62888096; -.
DR   KEGG; hal:VNG_6150G; -.
DR   PATRIC; fig|64091.14.peg.2182; -.
DR   HOGENOM; CLU_025112_0_0_2; -.
DR   InParanoid; Q9HHZ9; -.
DR   OMA; YHNCISG; -.
DR   OrthoDB; 50722at2157; -.
DR   PhylomeDB; Q9HHZ9; -.
DR   Proteomes; UP000000554; Plasmid pNRC200.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13401; AAA_22; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..308
FT                   /note="ORC1-type DNA replication protein 1"
FT                   /id="PRO_0000428863"
FT   BINDING         51..55
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         183
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         195
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   308 AA;  35315 MW;  3A22C07CA5AE2F2E CRC64;
     MITDARVLQP EFIPREVQHR DAEVNYLSSV LNPLTKGERA DSALLYGPSG VGKTCIAQFL
     VEQLRGEVVA LNYQYVNCWE DHSRFQTLYR LLDGIGKTVD IHRQSTPTDV HLNRLRTADD
     TSYVVILDEV DQLEDKSLLY DLYRIPHITM ILIANDEEDL FASLDQRLNS RLTDCERIHF
     DPYHENELIP ILHDRVHWGL EEDVISDSHL QLIAANAGGD ARVVIGILRH SARTARETGS
     DQITADLIEE VTPEAKSEIK QRTVDRFTPH QELLYNIITE HGEISPQDLY DAYCTRTDDP
     KTKRMVRN
 
 
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