ID   CDC61_METAC             Reviewed;         414 AA.
AC   Q8TUR2;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2003, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=ORC1-type DNA replication protein 1 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=cdc6-1; OrderedLocusNames=MA_0001;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM03455.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE010299; AAM03455.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_048064787.1; NC_003552.1.
DR   AlphaFoldDB; Q8TUR2; -.
DR   SMR; Q8TUR2; -.
DR   STRING; 188937.MA_0001; -.
DR   EnsemblBacteria; AAM03455; AAM03455; MA_0001.
DR   GeneID; 1471893; -.
DR   KEGG; mac:MA_0001; -.
DR   HOGENOM; CLU_025112_3_1_2; -.
DR   InParanoid; Q8TUR2; -.
DR   OMA; DMLGIIN; -.
DR   OrthoDB; 58376at2157; -.
DR   PhylomeDB; Q8TUR2; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..414
FT                   /note="ORC1-type DNA replication protein 1"
FT                   /id="PRO_0000151002"
FT   BINDING         70..74
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         213
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         225
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   414 AA;  47122 MW;  20C0F9120463F6B5 CRC64;
     MIKAQSLDGL FEKLLDGKSI FKNKEVLRPS YTPDLLLHRN EQINSLATIL VSALRGETPS
     NVLIYGKTGT GKTAVTRYVG KELERVSEDK SLFCSVVYIN CEVIDTQYRL LANLARHFEE
     EVPMTGWPTD QVFMKFKEAI DARDQVIIII LDEIDKLIKK GDDVLYNLSR INTDLRKAKV
     SMIGVSNDLK FTEFLDPRVK SSLGEEELIF PPYDAEQISD ILKQRAKMAY NDGVLGEMVI
     PLCAAFAAQE HGDARRALDL LRVSGEIAER ENQPQVLEEH VRRAQEKIEI DRVVEVVRTL
     PTQSKLVLYS IILLRSRGRE GKNVTTGEMY NVYRQLCHHI DVDILTQRRV TDLMSELDML
     GIVNAVVVSK GRYGRTKEIS LSVPVENTRK VLLEDYRLKP LVDFKTAVFN KMFS