CDC61_THEAC
ID CDC61_THEAC Reviewed; 347 AA.
AC Q9HKZ2;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Putative ORC1-type DNA replication protein 1;
GN Name=cdc6-1; OrderedLocusNames=Ta0451;
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
RN [2]
RP FUNCTION, AND GENE NAME.
RX PubMed=17108356; DOI=10.1093/nar/gkl864;
RA Haugland G.T., Shin J.H., Birkeland N.K., Kelman Z.;
RT "Stimulation of MCM helicase activity by a Cdc6 protein in the archaeon
RT Thermoplasma acidophilum.";
RL Nucleic Acids Res. 34:6337-6344(2006).
RN [3]
RP FUNCTION.
RX PubMed=18757887; DOI=10.1093/nar/gkn548;
RA Haugland G.T., Sakakibara N., Pey A.L., Rollor C.R., Birkeland N.K.,
RA Kelman Z.;
RT "Thermoplasma acidophilum Cdc6 protein stimulates MCM helicase activity by
RT regulating its ATPase activity.";
RL Nucleic Acids Res. 36:5602-5609(2008).
CC -!- FUNCTION: Involved in regulation of DNA replication (By similarity).
CC Has no effect on MCM helicase activity, either stimulatory or
CC inhibitory. Does not bind DNA. {ECO:0000250,
CC ECO:0000269|PubMed:17108356, ECO:0000269|PubMed:18757887}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000305}.
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DR EMBL; AL445064; CAC11593.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9HKZ2; -.
DR SMR; Q9HKZ2; -.
DR STRING; 273075.Ta0451m; -.
DR DNASU; 1457008; -.
DR EnsemblBacteria; CAC11593; CAC11593; CAC11593.
DR KEGG; tac:Ta0451; -.
DR eggNOG; arCOG00467; Archaea.
DR HOGENOM; CLU_025112_3_2_2; -.
DR OMA; YLFYENE; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF13401; AAA_22; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..347
FT /note="Putative ORC1-type DNA replication protein 1"
FT /id="PRO_0000421877"
FT BINDING 34..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 167
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 347 AA; 39110 MW; 42F6ADAEBDE8853C CRC64;
MARDGEIERI METVIKPTKN GITTNLILYG DSGTGKTVTM RYLAREIRDP QVVYVNAIAY
RYVKNVLIDF LSKFGIIVPE RSSYASLFTR IEGLLRNQGK NVILVIDEAA NILKGDYDGL
YYLFRSKDSF DVNISTIFVV MEDPAILFDA KIRKSYGIFS EIKFRRYTKG EIYQIVMNRA
VQSLTGEGYD EDVLDYIAEV SAEYGSARVG IDILAKAAHI AEYRRSPKIS FDDVRAARSM
ISPFVTESKL ASMDYEDLMV LLSICRCLSA SRFTDVDCIS RNLSVISEQY GKKDINLYDR
IKRLENNGII SSSIEGQGRG EGVKKVISIY DIPVSVLTEK IENLLSA
