CDC62_ARCFU
ID CDC62_ARCFU Reviewed; 376 AA.
AC O29563;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=ORC1-type DNA replication protein 2 {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=cdc6-2; OrderedLocusNames=AF_0695;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000255|HAMAP-Rule:MF_01407}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
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DR EMBL; AE000782; AAB90547.1; -; Genomic_DNA.
DR PIR; G69336; G69336.
DR AlphaFoldDB; O29563; -.
DR SMR; O29563; -.
DR STRING; 224325.AF_0695; -.
DR EnsemblBacteria; AAB90547; AAB90547; AF_0695.
DR KEGG; afu:AF_0695; -.
DR eggNOG; arCOG00467; Archaea.
DR HOGENOM; CLU_025112_3_0_2; -.
DR OMA; YLFYENE; -.
DR PhylomeDB; O29563; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02928; TIGR02928; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..376
FT /note="ORC1-type DNA replication protein 2"
FT /id="PRO_0000150983"
FT BINDING 73..77
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 209
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 376 AA; 42978 MW; 5939DA66F4EF72B2 CRC64;
MQVKRIIHIN VSFTLMLSWD ETLFKNPEVF DPDYIPDELL FRDGQIRQLV SCIKPAMLNS
SPINAFCLGP PSTGKTSTIR YVLREAERET GLLYSYIRIP RFKEPYKVFS KIFQDVLGQQ
SPPSGISKTV LMDRVWSNLD EPLLVVLDDI NFLGKNYANE ILYEILKAPD EYGVKVGIVA
AATDVKFPLL LDPFVGASFH YMEIHYPSYG YAEIEGILRK RVEHGFYEGV FDDGAFRRVV
ELAYRASDVR YGIYLLKAAG MNAESRGSRK VEERDVEVAH AGESLSFIAK ILTALNSEER
AVLRMIYSQN AISTGDLYEQ VCSEIKMSYR KYYNILEKLE RLKLIEISFG EKGRGKTRYV
QGKYDAEVVD RAMQLI