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CDC62_HALSA
ID   CDC62_HALSA             Reviewed;         264 AA.
AC   Q9HHY8;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=ORC1-type DNA replication protein 2;
GN   Name=orc2; OrderedLocusNames=VNG_6164G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC200.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1; PLASMID=pNRC200;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000305}.
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DR   EMBL; AE004438; AAG20835.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HHY8; -.
DR   SMR; Q9HHY8; -.
DR   EnsemblBacteria; AAG20835; AAG20835; VNG_6164G.
DR   KEGG; hal:VNG_6164G; -.
DR   PATRIC; fig|64091.14.peg.2193; -.
DR   HOGENOM; CLU_025112_2_2_2; -.
DR   InParanoid; Q9HHY8; -.
DR   OMA; YSISWPG; -.
DR   Proteomes; UP000000554; Plasmid pNRC200.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13401; AAA_22; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..264
FT                   /note="ORC1-type DNA replication protein 2"
FT                   /id="PRO_0000428864"
FT   BINDING         73..77
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         220
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         232
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   264 AA;  29146 MW;  094238C3DAFBFFCA CRC64;
     MTPDSSPSSV DDPLFESGHR IFANKDLLKI GHVPEADRIV GRDEEISKLA KRLNGAVHGY
     SPENVMIYGK TGTGKSLVSK HVCQRAQNAA QDGVEIGTAY IDCAEDNTET QAISSLAAKL
     NNESSTGISV PHTGLSTSKY YKLLWKTLDA QFDSVIIILD EIDLMNDDSV LMKLSRAEEA
     GKIDCSVGVI AISNKIQYVD NVNERVKSSF QHKELFFKPY DANQLREIMF NREDFSSSTT
     TYSISWPGWT ASSCSRARFK AATF
 
 
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