ID   CDC62_METAC             Reviewed;         373 AA.
AC   Q8TUI2;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=ORC1-type DNA replication protein 2 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=cdc6-2; OrderedLocusNames=MA_0085;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; AE010299; AAM03539.1; -; Genomic_DNA.
DR   RefSeq; WP_011020144.1; NC_003552.1.
DR   AlphaFoldDB; Q8TUI2; -.
DR   SMR; Q8TUI2; -.
DR   STRING; 188937.MA_0085; -.
DR   EnsemblBacteria; AAM03539; AAM03539; MA_0085.
DR   GeneID; 1471977; -.
DR   KEGG; mac:MA_0085; -.
DR   HOGENOM; CLU_025112_3_0_2; -.
DR   InParanoid; Q8TUI2; -.
DR   OMA; YLFYENE; -.
DR   OrthoDB; 93705at2157; -.
DR   PhylomeDB; Q8TUI2; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13191; AAA_16; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..373
FT                   /note="ORC1-type DNA replication protein 2"
FT                   /id="PRO_0000151003"
FT   BINDING         63..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         205
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         217
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   373 AA;  41952 MW;  0B9E6470B0E80EE0 CRC64;
     MTGNDILLWD ETLFKDLSVL EPDYLPEYFP HRDSQLNALR FALRPSLRGM RPLNCLLVGP
     PGTGKTSAVM KVFREVEVHA PGVVAVKVNC QIDSTRFAVI SRIYRQLFGI SPPNSGIAFR
     KLFETVVNFL VSSEKVLIVA LDDLNYLCCE GHANEVMYSL LRAHEQYPGA KIGVIGIVND
     ASDLYCLDSR VNSVFLPEEI SFLRYGEAEI LDILKDRVKY GFYPKVISDD VLELVVSYVE
     KTGDLRVGID LLRRSGFNAE RRGSRTISSG DVEKAYEASK LLHLCRGISL LSDSEKQLLE
     LIAKADDVKA GELYKSFHEL TQLGYTRFYG MVNRLQTLNY VDADFTGKGK RGRTRIIKAK
     YEAEDILNCL KKG