ID   CDC62_METMA             Reviewed;         373 AA.
AC   Q8PX44;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=ORC1-type DNA replication protein 2 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=cdc6-2; OrderedLocusNames=MM_1378;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; AE008384; AAM31074.1; -; Genomic_DNA.
DR   RefSeq; WP_011033324.1; NC_003901.1.
DR   AlphaFoldDB; Q8PX44; -.
DR   SMR; Q8PX44; -.
DR   STRING; 192952.MM_1378; -.
DR   EnsemblBacteria; AAM31074; AAM31074; MM_1378.
DR   GeneID; 44088992; -.
DR   KEGG; mma:MM_1378; -.
DR   PATRIC; fig|192952.21.peg.1595; -.
DR   eggNOG; arCOG00467; Archaea.
DR   HOGENOM; CLU_025112_3_0_2; -.
DR   OMA; YLFYENE; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13191; AAA_16; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..373
FT                   /note="ORC1-type DNA replication protein 2"
FT                   /id="PRO_0000151005"
FT   BINDING         63..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         205
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         217
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   373 AA;  42439 MW;  67E6B0E7A0EDEFCD CRC64;
     MTGNDILLWD ETLFKDLSVL EPDYLPEYFP HRDSQLNALR FALKPALRGM RPLNCLLVGP
     PGTGKTSAIM KTFREVEAHA PNVVTVKVNC QIDSTRFAVM SRIYRQLFGI SPPNSGIAFR
     KLFETVVNFL VSSEKVLIVA LDDLNYLCCE GHANEVMYSL LRAHEQYPGA KIGVIGIVND
     ASDLYCLDSR VNSVFLPEEV SFPRYEEGEI LDILKDRVRY GFYPKVISDE VLKLVVSYVE
     KTGDLRVGID LLRRSGFNAE RKGRRMILFE DVEKAYEASK LLHLCRGISL LSDPEKQLLE
     LIAKKDEIKA GELYKSFHEL TQLGYTRFYG MVNRLQTLNY VDADFTGKGK RGRTRIIKTK
     YEAEDILNCL KKA