ID   CDC64_HALSA             Reviewed;         410 AA.
AC   Q9HHJ7;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=ORC1-type DNA replication protein 4 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=orc4; OrderedLocusNames=VNG_6363G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC200.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; AE004438; AAG20983.1; -; Genomic_DNA.
DR   RefSeq; WP_010904194.1; NZ_BK010831.1.
DR   AlphaFoldDB; Q9HHJ7; -.
DR   SMR; Q9HHJ7; -.
DR   EnsemblBacteria; AAG20983; AAG20983; VNG_6363G.
DR   GeneID; 1449358; -.
DR   KEGG; hal:VNG_6363G; -.
DR   PATRIC; fig|64091.14.peg.2322; -.
DR   HOGENOM; CLU_025112_2_1_2; -.
DR   InParanoid; Q9HHJ7; -.
DR   OMA; REDAFQD; -.
DR   OrthoDB; 58376at2157; -.
DR   Proteomes; UP000000554; Plasmid pNRC200.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..410
FT                   /note="ORC1-type DNA replication protein 4"
FT                   /id="PRO_0000151001"
FT   BINDING         73..77
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         220
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         232
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   410 AA;  45633 MW;  93792082797E54A9 CRC64;
     MTPDSSPSSV DDPLFESGHR IFANKDLLKI GHVPEADRIV GRDEEISKLA KRLNGAVHGY
     SPENVMIYGK TGTGKSLVSK HVCQRAQNAA QDGVEIGTAY IDCAEDNTET QAISSLAAKL
     NDESSTGISV PHTGLSTSKY YKLLWKTLDA QFDSVIIILD EIDLMNDDSV LMKLSRAEEA
     GKIDCSVGVI AISNKIQYVD NVNERVKSSF QHKELFFKPY DANQLREIMF NREDAFQDGV
     LSEDVIPLSA AFAAQEHGDA RKAIDILRHA GEVAYEAGAE LVTEEHVRQA QQHAEKDRFR
     ELVNGAPTQA KAALLALTEL SVNSNDDAFL TSRVYDQYEH ICNHLDMDIL SVRRFRDILK
     EQAFLGVVEI EKINKGSAGG IHLQNRLIED SQVVRETILE DSRMQDWTRE