ID   CDC65_HALSA             Reviewed;         428 AA.
AC   Q9HHR1;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2002, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=ORC1-type DNA replication protein 5 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=orc5; OrderedLocusNames=VNG_6272G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC200.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG20915.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE004438; AAG20915.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q9HHR1; -.
DR   SMR; Q9HHR1; -.
DR   EnsemblBacteria; AAG20915; AAG20915; VNG_6272G.
DR   KEGG; hal:VNG_6272G; -.
DR   PATRIC; fig|64091.14.peg.2262; -.
DR   HOGENOM; CLU_025112_2_0_2; -.
DR   InParanoid; Q9HHR1; -.
DR   Proteomes; UP000000554; Plasmid pNRC200.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..428
FT                   /note="ORC1-type DNA replication protein 5"
FT                   /id="PRO_0000151000"
FT   BINDING         62..66
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         219
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         231
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   428 AA;  47948 MW;  41D0F5E6A66AA557 CRC64;
     MLHDDGDASV FVNRDLVEPD TIIDEERIVG RDEQLESVVS FLKPTLQGNR PPNMLLYGPA
     GTGKSLIIGA VTQQIIELCH SKGERFGVVQ VNCQPINTLD QAVYELVQTV ASDVGIEPGV
     PETGVSTKRK YRRLYDLINE HYDSVIFILD EIDLLVGRRA NDEPAYSKLL YQLSRASNTN
     DIEGQVSVAA LTNDPKFMEN IDGRAESSFN PRDIYFPDYD ATQLRQILEN RRDAFRQDAL
     TDDVLPLVSA FAAQSHGDAR KAIDLFRGAG DLADEQGDQT VREDHVRESQ DEIDKDRSLK
     LIAGLTTQKK ISLYATAAVA HCSSATRNSV PSPVGFQVYQ WVTEEIDADQ MTRETYVKYV
     KELSTYGLVS TARKSRGRGG GMYMDFTFRG DPESMMHRVV DDTRLERVGT ESERLHAVVN
     AQLREFEE