ID   CDC66_HALSA             Reviewed;         374 AA.
AC   Q9HN34;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=ORC1-type DNA replication protein 6 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=orc6; OrderedLocusNames=VNG_2271G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004437; AAG20387.1; -; Genomic_DNA.
DR   PIR; G84377; G84377.
DR   RefSeq; WP_010903688.1; NC_002607.1.
DR   AlphaFoldDB; Q9HN34; -.
DR   SMR; Q9HN34; -.
DR   STRING; 64091.VNG_2271G; -.
DR   PaxDb; Q9HN34; -.
DR   EnsemblBacteria; AAG20387; AAG20387; VNG_2271G.
DR   GeneID; 5954001; -.
DR   GeneID; 62887549; -.
DR   KEGG; hal:VNG_2271G; -.
DR   PATRIC; fig|64091.14.peg.1749; -.
DR   HOGENOM; CLU_025112_3_0_2; -.
DR   InParanoid; Q9HN34; -.
DR   OMA; YLFYENE; -.
DR   OrthoDB; 93705at2157; -.
DR   PhylomeDB; Q9HN34; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13191; AAA_16; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..374
FT                   /note="ORC1-type DNA replication protein 6"
FT                   /id="PRO_0000150999"
FT   BINDING         66..70
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         209
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         221
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   374 AA;  41720 MW;  C2C2678E169061EB CRC64;
     MDEDPEEGLL GWGETVFRDE HVFEIDYVPE VFRHRESQLQ TLQYALRPAV RGSRPLNVVA
     RGPPGTGKTT AVQKLFGELS GQPGVQTVRV NCQVDSTRYA VFSRVFEEIF DYEPPSSGIS
     FKKLFGQVAE RIADDDEVLV VALDDVNYLF YEDEAGDTLY SLLRAHETQP GAKVGVVVVS
     SDLELDVIEA LDGRVQSVFR PEEAYFSAYD RAEITDILRD RVEVGFREGA VAEPVLDAVG
     GRTDEAGDLR VGIDVLRRAG LHAESRASKT VEMEDVDAVY EDAKHVHLSR TLAALSDNER
     ALVRTVAEQE GDRAGDVYDV FNDRTDLGYT RYTEIVNKLD ELGVIDAAYE QRSGRGRSRT
     LRLTHDSEAV LERL