CDC67_HALSA
ID CDC67_HALSA Reviewed; 518 AA.
AC Q9HMS3;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=ORC1-type DNA replication protein 7 {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=orc7; OrderedLocusNames=VNG_2411G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2]
RP FUNCTION.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=14526006; DOI=10.1128/jb.185.20.5959-5966.2003;
RA Berquist B.R., DasSarma S.;
RT "An archaeal chromosomal autonomously replicating sequence element from an
RT extreme halophile, Halobacterium sp. strain NRC-1.";
RL J. Bacteriol. 185:5959-5966(2003).
RN [3]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA Berquist B.R., DasSarma P., DasSarma S.;
RT "Essential and non-essential DNA replication genes in the model halophilic
RT Archaeon, Halobacterium sp. NRC-1.";
RL BMC Genet. 8:31-31(2007).
RN [4]
RP FUNCTION.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=19502403; DOI=10.1128/jb.00210-09;
RA Coker J.A., DasSarma P., Capes M., Wallace T., McGarrity K., Gessler R.,
RA Liu J., Xiang H., Tatusov R., Berquist B.R., DasSarma S.;
RT "Multiple replication origins of Halobacterium sp. strain NRC-1: properties
RT of the conserved orc7-dependent oriC1.";
RL J. Bacteriol. 191:5253-5261(2009).
CC -!- FUNCTION: Involved in regulation of DNA replication. Required to
CC initiate DNA replication of the circular chromosome at a nearby
CC autonomously replicating sequence (ARS) oriC1. {ECO:0000255|HAMAP-
CC Rule:MF_01407, ECO:0000269|PubMed:14526006,
CC ECO:0000269|PubMed:19502403}.
CC -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC {ECO:0000269|PubMed:17559652}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
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DR EMBL; AE004437; AAG20498.1; -; Genomic_DNA.
DR PIR; F84391; F84391.
DR RefSeq; WP_010903800.1; NC_002607.1.
DR AlphaFoldDB; Q9HMS3; -.
DR SMR; Q9HMS3; -.
DR STRING; 64091.VNG_2411G; -.
DR PaxDb; Q9HMS3; -.
DR PRIDE; Q9HMS3; -.
DR EnsemblBacteria; AAG20498; AAG20498; VNG_2411G.
DR GeneID; 5953775; -.
DR KEGG; hal:VNG_2411G; -.
DR PATRIC; fig|64091.14.peg.1865; -.
DR HOGENOM; CLU_025112_3_1_2; -.
DR InParanoid; Q9HMS3; -.
DR OMA; DMLGIIN; -.
DR OrthoDB; 58376at2157; -.
DR PhylomeDB; Q9HMS3; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02928; TIGR02928; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..518
FT /note="ORC1-type DNA replication protein 7"
FT /id="PRO_0000150998"
FT REGION 165..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 94..98
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 318
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 330
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 518 AA; 58055 MW; CB0F63450C030B53 CRC64;
MTDDRSTDER RTADRDFEVD LDDVLDDEDD DEGLFDDLLS GEPIFENKEV LRPSYTPHEL
PHRNDQINNM ATILVAALRG ETPSNILIYG KTGTGKTASA KFVSQELEKT SKKYDVPCEV
EYINCEVTDT QYRVLAQLAN TFIDQNRAFV DARIADLSDL RAQADDDPNA LEIGGSPGDD
RTGNESSEGS DVSDSFSDLR ERFDSVAEID DRIDSLEADK AEMEQVPMTG WPTDRVYATF
FDAVDYVERV AVIMLDEIDK LVEKSGDDTL YNLSRMNSEL DNSRVSIIGI SNDLKFTDFL
DPRVKSSLGE EEIVFPPYDA NQLRDILQHR SDVAFKADAL SDDVLPLCAA FAAQEHGDAR
RALDLLRTAG ELAERDQAEN VTEDHVRRAQ DKIELDRVVE VVRTLPTQSK LVLYAILLLE
DNGVHNVNTG EVYNIYKTLC DELDADVLTQ RRVTDLISEL DMLGIVNAVV VSKGRYGRTK
EISLSVPVEE TEAVLEADSR LSDIEDITPF VQARFENN
