ID   CDC68_HALSA             Reviewed;         397 AA.
AC   Q9HQC7;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=ORC1-type DNA replication protein 8 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=orc8; OrderedLocusNames=VNG_1224G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; AE004437; AAG19588.1; -; Genomic_DNA.
DR   PIR; H84277; H84277.
DR   RefSeq; WP_010902884.1; NC_002607.1.
DR   AlphaFoldDB; Q9HQC7; -.
DR   SMR; Q9HQC7; -.
DR   STRING; 64091.VNG_1224G; -.
DR   PaxDb; Q9HQC7; -.
DR   EnsemblBacteria; AAG19588; AAG19588; VNG_1224G.
DR   GeneID; 5954418; -.
DR   GeneID; 62886727; -.
DR   KEGG; hal:VNG_1224G; -.
DR   PATRIC; fig|64091.14.peg.936; -.
DR   HOGENOM; CLU_025112_3_1_2; -.
DR   InParanoid; Q9HQC7; -.
DR   OMA; EMTETLF; -.
DR   OrthoDB; 58376at2157; -.
DR   PhylomeDB; Q9HQC7; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..397
FT                   /note="ORC1-type DNA replication protein 8"
FT                   /id="PRO_0000150997"
FT   BINDING         61..65
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         211
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         223
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   397 AA;  44288 MW;  CCD26118669C106C CRC64;
     MKTPFRDRVE LFANKDVLKD HYEPEEIRER DEEIDQYANA LQDVVDGWEP DNVFVYGKTG
     VGKTAVTRYM MDALEYEADD RDGVDSVTSV EVNCHHHPSS YQAAIALVNE LRGDTDSDPL
     TTGLSTSDVL NALFDEIEAR EGTVLIVLDE IDNLDDDDML LYQLPRAKTN GNIEDSQVAV
     VGISNDYTFR NDLSPKVQDT LCEREIKFPP YDANELVTIL DDRAERALSS GVLTGGVIPQ
     CAALAARDRG SARQAIDLLR ESVNVAIEDE RETVTEDDVE TAVRRVERGR IKDSIKDLTT
     HGQYVLLAVT QTAIADDTPV RAKELYEVYA DIAAEYASDP LSQRSVHDHL NDLSMLGFLR
     QHDRNYGRGG GQFFEYELDV DATMVQEAIA DADDATV