CDC6A_ARATH
ID CDC6A_ARATH Reviewed; 539 AA.
AC O82387; Q94CM2; Q94G54;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Cell division control protein 6 homolog {ECO:0000305};
DE Short=AtCDC6 {ECO:0000303|PubMed:11752380};
DE Short=AtCDC6A {ECO:0000305};
DE Short=Cdc6At {ECO:0000303|PubMed:11604464};
DE Short=Cell division control protein 6 homolog A {ECO:0000305};
GN Name=CDC6 {ECO:0000303|PubMed:11752380};
GN OrderedLocusNames=At2g29680 {ECO:0000312|Araport:AT2G29680};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=11604464; DOI=10.1093/jexbot/52.364.2239;
RA Ramos G.B., de Almeida Engler J., Ferreira P.C., Hemerly A.S.;
RT "DNA replication in plants: characterization of a cdc6 homologue from
RT Arabidopsis thaliana.";
RL J. Exp. Bot. 52:2239-2240(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, AND
RP INDUCTION.
RX PubMed=11752380; DOI=10.2307/3871527;
RA Castellano M.M., del Pozo J.C., Ramirez-Parra E., Brown S., Gutierrez C.;
RT "Expression and stability of Arabidopsis CDC6 are associated with
RT endoreplication.";
RL Plant Cell 13:2671-2686(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Ruelland E., Bergounioux C., Glab N.;
RT "Study of Arabidopsis thaliana homologue of cdc6p.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP INDUCTION.
RX PubMed=11669580; DOI=10.1023/a:1011848528377;
RA de Jager S.M., Menges M., Bauer U.M., Murra J.A.;
RT "Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-
RT regulated gene AtCDC6 and is a member of a multigene family with
RT differential activities.";
RL Plant Mol. Biol. 47:555-568(2001).
CC -!- FUNCTION: May be involved in the initiation of DNA replication. May
CC play a role in endoreduplication. Could act as one of the factors that
CC contributes to maintain endoreduplication competence.
CC {ECO:0000305|PubMed:11752380}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O82387-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O82387-2; Sequence=VSP_057638;
CC -!- TISSUE SPECIFICITY: Highly expressed in roots, flower buds and
CC etiolated seedlings. Expressed in leaves and stems (PubMed:11604464).
CC Highly expressed in proliferating cells such as root meristems, leaf
CC primordia and young growing leaves, as well as cells undergoing
CC endoreduplication cycles (PubMed:11752380).
CC {ECO:0000269|PubMed:11604464, ECO:0000269|PubMed:11752380}.
CC -!- INDUCTION: Cell cycle regulated. Up-regulated at the G1/S phase
CC transition and then decreases rapidly as cells progress into S-phase
CC (PubMed:11752380, PubMed:11669580). Degraded in a proteasome-dependent
CC manner in proliferating cells, but not in endoreduplicating cells
CC (PubMed:11752380). {ECO:0000269|PubMed:11669580,
CC ECO:0000269|PubMed:11752380}.
CC -!- MISCELLANEOUS: Cells expressing ectopically CDC6 have increased levels
CC of endopolyploidy. {ECO:0000269|PubMed:11752380}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000305}.
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DR EMBL; AF275940; AAK68875.1; -; mRNA.
DR EMBL; AJ271606; CAC81074.1; -; mRNA.
DR EMBL; AJ293020; CAC59688.1; -; mRNA.
DR EMBL; AC005496; AAC35241.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC08292.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08293.1; -; Genomic_DNA.
DR PIR; C84699; C84699.
DR RefSeq; NP_565686.1; NM_128522.1. [O82387-1]
DR RefSeq; NP_850137.1; NM_179806.2. [O82387-2]
DR AlphaFoldDB; O82387; -.
DR SMR; O82387; -.
DR IntAct; O82387; 4.
DR STRING; 3702.AT2G29680.1; -.
DR iPTMnet; O82387; -.
DR PaxDb; O82387; -.
DR PRIDE; O82387; -.
DR EnsemblPlants; AT2G29680.1; AT2G29680.1; AT2G29680. [O82387-1]
DR EnsemblPlants; AT2G29680.2; AT2G29680.2; AT2G29680. [O82387-2]
DR GeneID; 817518; -.
DR Gramene; AT2G29680.1; AT2G29680.1; AT2G29680. [O82387-1]
DR Gramene; AT2G29680.2; AT2G29680.2; AT2G29680. [O82387-2]
DR KEGG; ath:AT2G29680; -.
DR Araport; AT2G29680; -.
DR TAIR; locus:2060659; AT2G29680.
DR eggNOG; KOG2227; Eukaryota.
DR InParanoid; O82387; -.
DR OMA; DMLGIIN; -.
DR OrthoDB; 935804at2759; -.
DR PhylomeDB; O82387; -.
DR PRO; PR:O82387; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O82387; baseline and differential.
DR Genevisible; O82387; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0042023; P:DNA endoreduplication; TAS:UniProtKB.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR016314; Cdc6/18.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR PIRSF; PIRSF001767; Cdc6; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cell division; DNA replication; Nucleus;
KW Reference proteome.
FT CHAIN 1..539
FT /note="Cell division control protein 6 homolog"
FT /id="PRO_0000432983"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 35..38
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000305"
FT VAR_SEQ 280..310
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_057638"
FT CONFLICT 76
FT /note="K -> N (in Ref. 1; AAK68875)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="V -> E (in Ref. 1; AAK68875)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="L -> F (in Ref. 1; AAK68875)"
FT /evidence="ECO:0000305"
FT CONFLICT 506
FT /note="L -> H (in Ref. 1; AAK68875)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 539 AA; 59841 MW; 4D44B3BCEDC6E184 CRC64;
MPAIAGPSSS PQKHVVGSRS ESIGGVRSAE VNTSRKRKLI SDSAAEVSAT VVLPVNSIST
PMKWKSPRRC AVSIPKTSDE EIKEDSNEKL ENPVISVCLE VKSKWNPKDD EQMKAVKEAL
HVSKAPSTVV CREDEQRRVF EFVKGCMEQK KAGSLYICGC PGTGKSLSME KVRLQAEEWA
KQAGLHCPET VSVNCTSLTK STDIFSKILG NYESGKKANG SFSPLQQLQR LFSQKQQQSR
SKMMLIIADE MDYLITRDRG VLHELFMLTT LPLSRCILIG TVFCVINVHF LKSVSYGQTS
FKFKVRICPP GVANAIDLAD RFLPKLKSLN CKPLVVTFRA YSKDQILRIL QERLVALPFV
AFQSNALEIC ARKVSAASGD MRKALCVCRS ALEILEIEVR GSIDQEPKGP VPECQVVKMD
HMIAALSKTF KSPIVDTIQS LPQHQQIIVC SAAKAFRGSK KDRTIAELNK LYLEICKSSM
ITPAGITEFS NMCTVLNDQG ILKLSLARDD KLKRVSLRVD EADITFALKE IRFFRNCLL
