CDC6A_HALMA
ID CDC6A_HALMA Reviewed; 426 AA.
AC Q5UWT2;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=ORC1-type DNA replication protein 1 {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=cdc6a; OrderedLocusNames=rrnB0063;
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000255|HAMAP-Rule:MF_01407}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
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DR EMBL; AY596298; AAV48271.1; -; Genomic_DNA.
DR RefSeq; WP_011225048.1; NZ_CP039136.1.
DR AlphaFoldDB; Q5UWT2; -.
DR SMR; Q5UWT2; -.
DR STRING; 272569.rrnB0063; -.
DR EnsemblBacteria; AAV48271; AAV48271; rrnB0063.
DR GeneID; 40151031; -.
DR GeneID; 64824907; -.
DR KEGG; hma:rrnB0063; -.
DR PATRIC; fig|272569.17.peg.4101; -.
DR eggNOG; arCOG00467; Archaea.
DR HOGENOM; CLU_025112_3_1_2; -.
DR OMA; EIHFPPY; -.
DR Proteomes; UP000001169; Chromosome II.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02928; TIGR02928; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..426
FT /note="ORC1-type DNA replication protein 1"
FT /id="PRO_0000150990"
FT BINDING 62..66
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 211
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 223
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 426 AA; 47960 MW; B9608805F7B0D03F CRC64;
MGLEPFSPDS TIFRDESVLR DGYQPDRLIE RDTELEQYQS ALKPVINGAP PKNLFLYGQT
GVGKTLSSRM VVERLIEDQQ NIDGVDVQVI ELNCKSLNSS YQVAANLINQ FRPPTEQIKP
TGYPSGMIYN MLFDELEALD ATHCLIVLDE IDAIGNDDDI LYKLPRANDN ENVEDTLVGV
IGISNDFTFR DNLSARVKDS LADEEIHFPP YDANELGNIL KQRAGEAFHG TSAQRLDDGS
YELQSDILEG DVVPLCAAFA AQDSGSARQA LKRLYKAGDL ARDEESDVIT GAHVRQADEI
VERDKVRDEL TRLPTQSKLT LYSLLLLERE DETPSKRNRI YERYVMAAKR IDADVRTDRT
IHDRLSQLTL KGFLDVDEQN KGPKGGSYYE YEFSIRADLA QEVLQEDERL AELFATDETS
TTLDSF
