ID   CDC6A_HALSA             Reviewed;         413 AA.
AC   Q9HSW6;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2002, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=ORC1-type DNA replication protein 10 {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=orc10; OrderedLocusNames=VNG_0045C;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA   Berquist B.R., DasSarma P., DasSarma S.;
RT   "Essential and non-essential DNA replication genes in the model halophilic
RT   Archaeon, Halobacterium sp. NRC-1.";
RL   BMC Genet. 8:31-31(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000255|HAMAP-Rule:MF_01407}.
CC   -!- DISRUPTION PHENOTYPE: Essential for normal growth.
CC       {ECO:0000269|PubMed:17559652}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG18684.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE004437; AAG18684.1; ALT_INIT; Genomic_DNA.
DR   PIR; H84164; H84164.
DR   AlphaFoldDB; Q9HSW6; -.
DR   SMR; Q9HSW6; -.
DR   STRING; 64091.VNG_0045C; -.
DR   PaxDb; Q9HSW6; -.
DR   EnsemblBacteria; AAG18684; AAG18684; VNG_0045C.
DR   KEGG; hal:VNG_0045C; -.
DR   PATRIC; fig|64091.14.peg.26; -.
DR   HOGENOM; CLU_025112_3_1_2; -.
DR   InParanoid; Q9HSW6; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..413
FT                   /note="ORC1-type DNA replication protein 10"
FT                   /id="PRO_0000150996"
FT   BINDING         63..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         211
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         223
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   413 AA;  45833 MW;  DAA7AC49C8257FCE CRC64;
     MLSMPSFERK QNIFANKDAL GESYQPNKIE ERDDEIEKYM DALQPVIDGW EPNNIFVYGN
     TGVGKTAVTD HLLDQLQTDV EAYDDVTLSV IYLNCKTLSS SYQVAVELVN KLRRPGAEIS
     STGYPQQSVF KKLYQELEAL GGTILIVLDE VDAIGDRDDL LYELPRARSQ GNLEDAKVGI
     IGISNDYKFQ EQLDPRVQDT LCERELQFPP YDALELANIL DSRTDIAIAD DSLAEGVTQH
     CAALAARDSG SARQALDLLR LAGELAENQD ADAISTDHVE AARSELERER VEEGMRELTT
     HGRLTLLAVV SKAAKADTPS RTRAIYDEYA SLCKSAANTD DPLKQRSVHN HLSDLHMLGI
     LSKYENRSGS RGNYYSYELD VPFESAVDAM ADVLMLDAEI EKMEGLASRN GVL