ID   CDC6_ORYSJ              Reviewed;         515 AA.
AC   Q5N897; A0A0P0VAJ2; Q0JHL9; Q5N896;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Cell division control protein 6 homolog {ECO:0000305};
GN   Name=CDC6 {ECO:0000305};
GN   OrderedLocusNames=Os01g0856000 {ECO:0000312|EMBL:BAF06759.2},
GN   LOC_Os01g63710 {ECO:0000305};
GN   ORFNames=OJ1402_H07.11-1 {ECO:0000312|EMBL:BAD82303.1},
GN   OJ1402_H07.11-2 {ECO:0000312|EMBL:BAD82304.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: May be involved in the initiation of DNA replication.
CC       {ECO:0000250|UniProtKB:O82387}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O82387}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5N897-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5N897-2; Sequence=VSP_057639, VSP_057640;
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000305}.
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DR   EMBL; AP003415; BAD82303.1; -; Genomic_DNA.
DR   EMBL; AP003415; BAD82304.1; -; Genomic_DNA.
DR   EMBL; AP008207; BAF06759.2; -; Genomic_DNA.
DR   EMBL; AP014957; BAS75291.1; -; Genomic_DNA.
DR   EMBL; AP014957; BAS75292.1; -; Genomic_DNA.
DR   EMBL; AK107439; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK107451; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q5N897; -.
DR   SMR; Q5N897; -.
DR   STRING; 4530.OS01T0856000-02; -.
DR   PRIDE; Q5N897; -.
DR   EnsemblPlants; Os01t0856000-01; Os01t0856000-01; Os01g0856000. [Q5N897-2]
DR   EnsemblPlants; Os01t0856000-02; Os01t0856000-02; Os01g0856000. [Q5N897-1]
DR   Gramene; Os01t0856000-01; Os01t0856000-01; Os01g0856000. [Q5N897-2]
DR   Gramene; Os01t0856000-02; Os01t0856000-02; Os01g0856000. [Q5N897-1]
DR   eggNOG; KOG2227; Eukaryota.
DR   InParanoid; Q5N897; -.
DR   OMA; DMLGIIN; -.
DR   PlantReactome; R-OSA-9640882; Assembly of pre-replication complex.
DR   PlantReactome; R-OSA-9640887; G1/S transition.
DR   PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   Genevisible; Q5N897; OS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041083; AAA_lid_10.
DR   InterPro; IPR016314; Cdc6/18.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF17872; AAA_lid_10; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   PIRSF; PIRSF001767; Cdc6; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell cycle; Cell division; DNA replication; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..515
FT                   /note="Cell division control protein 6 homolog"
FT                   /id="PRO_0000432985"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..58
FT                   /note="MPTLRSATASASTAGTASPTAIATPRSAKRRLTSPRRAAGSPDASQFTSPHK
FT                   SPNVGI -> MRSNCSILQ (in isoform 2)"
FT                   /id="VSP_057639"
FT   VAR_SEQ         92..117
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_057640"
SQ   SEQUENCE   515 AA;  57223 MW;  0D74C812AFC1FA27 CRC64;
     MPTLRSATAS ASTAGTASPT AIATPRSAKR RLTSPRRAAG SPDASQFTSP HKSPNVGIVG
     TPKLLSASPR SSRKRLYGDF VAAEKPKWNP RGKSPESHFS RAQSSDWDLT KEFICSADPA
     QMQVVKEALH VATVPSCGLV CRDDEQSRVL EFCKGCVEQE RSGSLYVCGC PGTGKTLSIN
     KVKESVARWA DETGMETPDA LSINCTSLAK THEIFSKILA KFQTRKKATC KLSPLQQLQT
     MFSHKESAPR RMLLVVVDEM DYLITRDRAV LHDLFMLTTY QFSRCILIGI ANAIDLADRF
     LPKLESLNCK PLVVTFRAYS KDQISDIIKH RLKVLEYDVF EPLALEFCAR KVAAASGDMR
     KALGVCRSAV EVFEARLQES SDQEFGLVTF DHMDIALSKA FKSPVVDSIL CLPQHQQMVL
     CALANTFHHC KKKATTLGEL NKSYIEICRS TQVPAVGMLE FSNMCMVLSD QGFMKLGQSK
     EDKLRRVMLQ IDSSDITFAF KGNRFFQKCL EQQKF