ID   CDC6_PYRAB              Reviewed;         419 AA.
AC   Q9V2F2; G8ZFV7;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=ORC1-type DNA replication protein {ECO:0000255|HAMAP-Rule:MF_01407};
GN   Name=cdc6; OrderedLocusNames=PYRAB01220; ORFNames=PAB2265;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
RN   [3]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=17452353; DOI=10.1093/nar/gkm212;
RA   Matsunaga F., Glatigny A., Mucchielli-Giorgi M.H., Agier N., Delacroix H.,
RA   Marisa L., Durosay P., Ishino Y., Aggerbeck L., Forterre P.;
RT   "Genomewide and biochemical analyses of DNA-binding activity of Cdc6/Orc1
RT   and Mcm proteins in Pyrococcus sp.";
RL   Nucleic Acids Res. 35:3214-3222(2007).
CC   -!- FUNCTION: Involved in regulation of DNA replication (By similarity).
CC       Binds specifically to the oriC region. {ECO:0000255|HAMAP-
CC       Rule:MF_01407, ECO:0000269|PubMed:17452353}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01407}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB49046.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CCE69498.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ248283; CAB49046.1; ALT_INIT; Genomic_DNA.
DR   EMBL; HE613800; CCE69498.1; ALT_INIT; Genomic_DNA.
DR   PIR; G75199; G75199.
DR   RefSeq; WP_048146489.1; NC_000868.1.
DR   AlphaFoldDB; Q9V2F2; -.
DR   SMR; Q9V2F2; -.
DR   STRING; 272844.PAB2265; -.
DR   EnsemblBacteria; CAB49046; CAB49046; PAB2265.
DR   GeneID; 1495009; -.
DR   KEGG; pab:PAB2265; -.
DR   PATRIC; fig|272844.11.peg.135; -.
DR   eggNOG; arCOG00467; Archaea.
DR   HOGENOM; CLU_025112_3_1_2; -.
DR   OMA; DMLGIIN; -.
DR   OrthoDB; 58376at2157; -.
DR   PhylomeDB; Q9V2F2; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02928; TIGR02928; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..419
FT                   /note="ORC1-type DNA replication protein"
FT                   /id="PRO_0000151011"
FT   BINDING         72..76
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         220
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT   BINDING         232
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   419 AA;  47930 MW;  C77A5E5E64C9D840 CRC64;
     MSEGEQLHLD KLFERLLKAR KIFKNKEVLR HSYTPKDLPH RHEQIEALAQ ILVPVLKGET
     PSNIFVYGKT GTGKTVTVKF VTEELKKVSQ KYNIPVEVIY INCEIVDTHY RVLANIVNHF
     KDETGIEVPL VGWPTDEVYA KLKQVIDMKE RFVIIVLDEI DKLVKKSGDE VLYSLTRINT
     ELKRAKVSVI GISNDLKFKE YLDPRVLSSL SEEEVVFPPY DANQLKDILT QRAEEAFYPG
     VLEEGVIPLC AALAAREHGD ARKALDLLRV AGEIAEREGA SKVTEKHVWR AQEKIEQDMM
     EEVIKTLPLQ SKVLLYAIVL LDENGDLPAN TGEVYSVYRE LCEYLDLEPL TQRRISDLIN
     ELDMLGIINA KVVSKGRYGR TKEIRLNVTP YKIRNVFRYD YAIQPLLTVS LKGGQRRLL