CDC6_PYRHO
ID CDC6_PYRHO Reviewed; 419 AA.
AC O57864;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=ORC1-type DNA replication protein {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=cdc6; OrderedLocusNames=PH0124;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000255|HAMAP-Rule:MF_01407}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA29193.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000001; BAA29193.1; ALT_INIT; Genomic_DNA.
DR PIR; B71233; B71233.
DR RefSeq; WP_048053038.1; NC_000961.1.
DR AlphaFoldDB; O57864; -.
DR SMR; O57864; -.
DR STRING; 70601.3256510; -.
DR EnsemblBacteria; BAA29193; BAA29193; BAA29193.
DR GeneID; 1444020; -.
DR KEGG; pho:PH0124; -.
DR eggNOG; arCOG00467; Archaea.
DR OMA; DMLGIIN; -.
DR OrthoDB; 58376at2157; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02928; TIGR02928; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding.
FT CHAIN 1..419
FT /note="ORC1-type DNA replication protein"
FT /id="PRO_0000151013"
FT BINDING 72..76
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 220
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 232
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 419 AA; 48094 MW; 59F0C56A66B04CEF CRC64;
MNEGEQLHLD QLFEKLLKAR KIFKNKEVLR HSYTPKDLPH RHEQIETLAQ ILVPVLKGET
PSNIFVYGKT GTGKTVTVKF VTEELKKVSH KYNIPVDVIY INCEIVDTHY RVLANIVNHF
KHETGIEVPL VGWPTDEVYA KLKQVIDMRE RFVIIVLDEI DKLVKKSGDE VLYSLTRINT
ELKRAKVSVI GISNDLKFKE YLDPRVLSSL SEEEVVFPPY DANQLRDILM QRAEEAFYPG
VLDDGVIPLC AALAAREHGD ARKALDLLRV AGEIAEREGA SKVTEKHVWK AQEKIEQDMM
EEVIKTLPLQ SKVLLYAIVL LDENGELPAN TGEVYSVYRD LCEYLDLEPL TQRRISDLIN
ELDMLGIINA KVVSKGRYGR TKEIRLNVTP YKIRNVFRYD YTIQPLLAIS LKDSQRRLV
