CDC6_THEVO
ID CDC6_THEVO Reviewed; 404 AA.
AC Q97AP1;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2002, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=ORC1-type DNA replication protein {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=cdc6; OrderedLocusNames=TV0769; ORFNames=TVG0773033;
OS Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS 15438 / GSS1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT Thermoplasma volcanium.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000255|HAMAP-Rule:MF_01407}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB59911.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000011; BAB59911.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_010917016.1; NC_002689.2.
DR AlphaFoldDB; Q97AP1; -.
DR SMR; Q97AP1; -.
DR STRING; 273116.14324985; -.
DR DNASU; 1441864; -.
DR EnsemblBacteria; BAB59911; BAB59911; BAB59911.
DR GeneID; 1441864; -.
DR KEGG; tvo:TVG0773033; -.
DR eggNOG; arCOG00467; Archaea.
DR HOGENOM; CLU_025112_3_1_2; -.
DR OMA; DMLGIIN; -.
DR OrthoDB; 58376at2157; -.
DR PhylomeDB; Q97AP1; -.
DR Proteomes; UP000001017; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02928; TIGR02928; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding.
FT CHAIN 1..404
FT /note="ORC1-type DNA replication protein"
FT /id="PRO_0000151025"
FT BINDING 64..68
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 205
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 217
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 404 AA; 45905 MW; 872F160DF97822AE CRC64;
MDNPFSKFTN SRTIQADLSL LEENYIPDSF PHREKQINDM VTILSSIMRN SRPSNIIVYG
KTGTGKTSTT KYVTRMLQEA TSNVEVIYVN CEIYDSPYSI LVYVANFAGG EKIPELGWPV
DRIYREAVDR INGTGKFFVI VLDEMDRLIK KSGGDSLYVL LKLMTDVENV KVSMIGITND
TTLLENLDSR IKSRLNQESI VFPPYNATEI RDIIASRLEK VFGPGVVDDT AINLCAAIGA
QEHGDARKAI DLMRIAIEIA IRENRLKVTE KEVYEARDKY EMNVMHEAIN TLPIHSKIVL
LSAIVTQEIE PNSVITGEIY ENYRRICEDL GFTPLTPRRI SDLLTELSDY GLIVVDERNM
GKYGRTRGFS VVKEIETIKK YLMEDENLSM FKTSKMTKQA RFDS
