CDC73_ARATH
ID CDC73_ARATH Reviewed; 415 AA.
AC Q9LJ87;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein CDC73 homolog {ECO:0000303|PubMed:20463090};
DE AltName: Full=Protein PLANT HOMOLOGOUS TO PARAFIBROMIN {ECO:0000303|PubMed:20363855};
GN Name=CDC73 {ECO:0000303|PubMed:20463090};
GN Synonyms=PHP {ECO:0000303|PubMed:20363855};
GN OrderedLocusNames=At3g22590 {ECO:0000312|Araport:AT3G22590};
GN ORFNames=F16J14.15 {ECO:0000312|EMBL:BAB01474.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION IN THE PAF1 COMPLEX, FUNCTION, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=20363855; DOI=10.1104/pp.110.155838;
RA Park S., Oh S., Ek-Ramos J., van Nocker S.;
RT "PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and
RT assists in regulating expression of genes within H3K27ME3-enriched
RT chromatin.";
RL Plant Physiol. 153:821-831(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=20463090; DOI=10.1104/pp.110.158386;
RA Yu X., Michaels S.D.;
RT "The Arabidopsis Paf1c complex component CDC73 participates in the
RT modification of FLOWERING LOCUS C chromatin.";
RL Plant Physiol. 153:1074-1084(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=22511887; DOI=10.1371/journal.pgen.1002652;
RA Dorcey E., Rodriguez-Villalon A., Salinas P., Santuari L., Pradervand S.,
RA Harshman K., Hardtke C.S.;
RT "Context-dependent dual role of SKI8 homologs in mRNA synthesis and
RT turnover.";
RL PLoS Genet. 8:E1002652-E1002652(2012).
CC -!- FUNCTION: Component of the PAF1 complex (PAF1C) which is involved in
CC histone modifications such as methylation on histone H3 'Lys-4'
CC (H3K4me3) (PubMed:20363855). Involved in regulation of flowering time.
CC Required for the expression of the flowering repressors FLC and MADS-
CC box genes of the MAF family. Required for histone H3 trimethylation on
CC 'Lys-4' (H3K4me3) at the FLC locus (PubMed:20363855, PubMed:20463090).
CC Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus
CC (PubMed:20363855). {ECO:0000269|PubMed:20363855,
CC ECO:0000269|PubMed:20463090}.
CC -!- SUBUNIT: Component of the nuclear PAF1 complex (PAF1C), which consists
CC of VIP2/ELF7/PAF1, VIP3/SKI8/WDR61, VIP4/LEO1, VIP5/RTF1,
CC VIP6/ELF8/CTR9 and CDC73. {ECO:0000269|PubMed:20363855}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20363855,
CC ECO:0000269|PubMed:20463090}.
CC -!- TISSUE SPECIFICITY: Expressed in root tips, shoot apex, young leaves
CC and flowers, especially in stamen filaments and carpels.
CC {ECO:0000269|PubMed:20463090}.
CC -!- DISRUPTION PHENOTYPE: Early flowering. {ECO:0000269|PubMed:20363855,
CC ECO:0000269|PubMed:20463090}.
CC -!- SIMILARITY: Belongs to the CDC73 family. {ECO:0000305}.
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DR EMBL; AP000731; BAB01474.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76656.1; -; Genomic_DNA.
DR EMBL; AY065437; AAL38878.1; -; mRNA.
DR EMBL; AY142611; AAN13180.1; -; mRNA.
DR RefSeq; NP_188898.1; NM_113158.3.
DR AlphaFoldDB; Q9LJ87; -.
DR SMR; Q9LJ87; -.
DR STRING; 3702.AT3G22590.1; -.
DR PaxDb; Q9LJ87; -.
DR PRIDE; Q9LJ87; -.
DR ProteomicsDB; 224388; -.
DR EnsemblPlants; AT3G22590.1; AT3G22590.1; AT3G22590.
DR GeneID; 821831; -.
DR Gramene; AT3G22590.1; AT3G22590.1; AT3G22590.
DR KEGG; ath:AT3G22590; -.
DR Araport; AT3G22590; -.
DR TAIR; locus:2077076; AT3G22590.
DR eggNOG; KOG3786; Eukaryota.
DR HOGENOM; CLU_025849_3_0_1; -.
DR InParanoid; Q9LJ87; -.
DR OMA; CAFHLKY; -.
DR OrthoDB; 720340at2759; -.
DR PhylomeDB; Q9LJ87; -.
DR PRO; PR:Q9LJ87; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJ87; baseline and differential.
DR Genevisible; Q9LJ87; AT.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0051568; P:histone H3-K4 methylation; IMP:TAIR.
DR GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR Gene3D; 3.40.50.11990; -; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; PTHR12466; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 1: Evidence at protein level;
KW Flowering; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..415
FT /note="Protein CDC73 homolog"
FT /id="PRO_0000432764"
SQ SEQUENCE 415 AA; 47544 MW; 03D84CC54CED0594 CRC64;
MDPLSVLKEF TIRGDIDKIE RVGANYRFGS EYSFPCATET AYRSKSGSLY TLEALVHYVK
NQQLKHGEYM QSTVKNSVPA VTLPDRKPLL DYLTGRVASS DSIDFLLLQQ QNAQSQKQNE
EYRPDQDNSA FVSRENAIAD MEVEDFGKSG EDVDYIMLIR SNERPLKSRD AILQCKNRDF
YSVLVNSTKR EEERQRIESH QRKDGLVAKS RLMGAEERGI VGFSSGGGDD NGYDANPKSK
LHFKAGKIGE GVPIILVPSA FQTLITIYNV KEFLEDGVYI PNDVKAKEMK GLKPDCITVQ
KKFSRDRERV VTAYEVRDKP SALKPDDWDR VVAVFVLGKD WQFKDWPFKD HVEIFNKIIG
FFLRFEDDSI ESAKTVKQWN VKIISISKNK RHQDRAAALE VWEKLEEFVR SRSHS
