CDC73_CAEEL
ID CDC73_CAEEL Reviewed; 517 AA.
AC Q9N5U5;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 4.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Cell division cycle protein 73 {ECO:0000250|UniProtKB:Q06697};
DE AltName: Full=RNA polymerase-associated protein CDC73 {ECO:0000250|UniProtKB:Q06697};
GN Name=cdc-73 {ECO:0000312|WormBase:F35F11.1};
GN ORFNames=F35F11.1 {ECO:0000312|WormBase:F35F11.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|EMBL:CCD70582.2};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=24721716; DOI=10.1016/j.ydbio.2014.04.002;
RA Kubota Y., Tsuyama K., Takabayashi Y., Haruta N., Maruyama R., Iida N.,
RA Sugimoto A.;
RT "The PAF1 complex is involved in embryonic epidermal morphogenesis in
RT Caenorhabditis elegans.";
RL Dev. Biol. 391:43-53(2014).
CC -!- FUNCTION: Component of the PAF1 complex which is a multifunctional
CC complex involved in transcription initiation via genetic interactions
CC with TATA-binding proteins, elongation and transcription-coupled
CC histone modification. {ECO:0000250|UniProtKB:Q06697}.
CC -!- SUBUNIT: Component of the PAF1 complex which consists of at least cdc-
CC 73, ctr-9, leo-1, pafo-1 and rtfo-1. {ECO:0000250|UniProtKB:Q06697}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24721716}.
CC Note=Nuclear localization depends on pafo-1, leo-1 and ctr-9.
CC {ECO:0000303|PubMed:24721716}.
CC -!- DISRUPTION PHENOTYPE: RNAi mediated knock-down is embryonic lethal.
CC Embryogenesis proceeds more slowly, with embryos displaying defects in
CC the positioning and shape of epidermal cells. 60% of embryos arrest at
CC the bean stage of embryogenesis without any significant change in body
CC shape. Nuclear localization of rtf-1 is unaffected.
CC {ECO:0000269|PubMed:24721716}.
CC -!- SIMILARITY: Belongs to the CDC73 family. {ECO:0000255}.
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DR EMBL; FO081297; CCD70582.2; -; Genomic_DNA.
DR RefSeq; NP_500465.4; NM_068064.6.
DR AlphaFoldDB; Q9N5U5; -.
DR SMR; Q9N5U5; -.
DR ComplexPortal; CPX-966; PAF1 complex.
DR DIP; DIP-25821N; -.
DR STRING; 6239.F35F11.1; -.
DR EPD; Q9N5U5; -.
DR PaxDb; Q9N5U5; -.
DR PeptideAtlas; Q9N5U5; -.
DR PRIDE; Q9N5U5; -.
DR EnsemblMetazoa; F35F11.1.1; F35F11.1.1; WBGene00018064.
DR GeneID; 177160; -.
DR KEGG; cel:CELE_F35F11.1; -.
DR UCSC; F35F11.1; c. elegans.
DR CTD; 177160; -.
DR WormBase; F35F11.1; CE48035; WBGene00018064; cdc-73.
DR eggNOG; KOG3786; Eukaryota.
DR GeneTree; ENSGT00390000001114; -.
DR HOGENOM; CLU_025849_0_1_1; -.
DR InParanoid; Q9N5U5; -.
DR OMA; CAFHLKY; -.
DR OrthoDB; 720340at2759; -.
DR PhylomeDB; Q9N5U5; -.
DR Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-CEL-201722; Formation of the beta-catenin:TCF transactivating complex.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR PRO; PR:Q9N5U5; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00018064; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IBA:GO_Central.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0016571; P:histone methylation; IC:ComplexPortal.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:ComplexPortal.
DR Gene3D; 3.40.50.11990; -; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; PTHR12466; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..517
FT /note="Cell division cycle protein 73"
FT /id="PRO_0000431511"
FT REGION 124..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 58093 MW; 6D8CEE84B50EC47C CRC64;
MDPLEALQKH VQRPEEFPLR EVTVSGISYV AFGDYAYKKD TETSLQIYGK SDEFYSLESL
VVFLKYSHEN HGVYVKEAAA AGVRAVTRID RKNVTEYLQG DRTDFPALMN QVNPLSLRQL
LHSSEPEAKK PRLDGEAAGE PMDTSTSDEP QESAVSAAKK EVEIRALNDN LTKDRIAEMR
RKRQSHREKG IVTIDESLST LTSASLPKTR IHKTRENVML GARDLSNVLD IITSAQRQWD
LNEKKEKVAA VHATNLSKDQ SGAAGGQQQR SGYSRYAQEA FAHEKTKEIQ TEGSFIGSNF
SSIKQGHHAV QKAPDAPPGR PPLAKPIQLL TSSTATSSGS SAAQNGSKRT SRSPIIIVPS
AMNTMINLYN VRDILQNFSY VPVDQRRKET NKKPVDLAIQ RQKNGVTYNI RVIDNAEKLA
NDDWDRVIAV FVMGVAWQFK GWKWNGNPTD IFTHIPAFHF HVDQDKPVAQ VMQWNVHKIP
VSATKRHMDK ARFSQVWETI ENFVRKNKPH LTARLGL
