CDC73_CHICK
ID CDC73_CHICK Reviewed; 531 AA.
AC Q5ZLM0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Parafibromin;
DE AltName: Full=Cell division cycle protein 73 homolog;
GN Name=CDC73; ORFNames=RCJMB04_5j4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Tumor suppressor probably involved in transcriptional and
CC post-transcriptional control pathways. May be involved in cell cycle
CC progression through the regulation of cyclin D1/PRAD1 expression.
CC Component of the PAF1 complex (PAF1C) which has multiple functions
CC during transcription by RNA polymerase II. PAF1C associates with RNA
CC polymerase II, is involved in transcriptional elongation and in histone
CC modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC CDC73, PAF1, LEO1, CTR9 and RTF1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDC73 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ719714; CAG31373.1; -; mRNA.
DR RefSeq; NP_001026436.1; NM_001031265.1.
DR AlphaFoldDB; Q5ZLM0; -.
DR SMR; Q5ZLM0; -.
DR STRING; 9031.ENSGALP00000003888; -.
DR PaxDb; Q5ZLM0; -.
DR Ensembl; ENSGALT00000003897; ENSGALP00000003888; ENSGALG00000002469.
DR GeneID; 424356; -.
DR KEGG; gga:424356; -.
DR CTD; 79577; -.
DR VEuPathDB; HostDB:geneid_424356; -.
DR eggNOG; KOG3786; Eukaryota.
DR GeneTree; ENSGT00390000001114; -.
DR HOGENOM; CLU_025849_0_1_1; -.
DR InParanoid; Q5ZLM0; -.
DR OMA; CAFHLKY; -.
DR OrthoDB; 720340at2759; -.
DR PhylomeDB; Q5ZLM0; -.
DR TreeFam; TF313016; -.
DR Reactome; R-GGA-201722; Formation of the beta-catenin:TCF transactivating complex.
DR Reactome; R-GGA-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-GGA-75955; RNA Polymerase II Transcription Elongation.
DR PRO; PR:Q5ZLM0; -.
DR Proteomes; UP000000539; Chromosome 8.
DR Bgee; ENSGALG00000002469; Expressed in muscle tissue and 13 other tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.
DR GO; GO:0016570; P:histone modification; IEA:InterPro.
DR GO; GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:1902808; P:positive regulation of cell cycle G1/S phase transition; ISS:UniProtKB.
DR GO; GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IBA:GO_Central.
DR GO; GO:0019827; P:stem cell population maintenance; ISS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR Gene3D; 3.40.50.11990; -; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; PTHR12466; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Nucleus; Reference proteome; Transcription; Tumor suppressor.
FT CHAIN 1..531
FT /note="Parafibromin"
FT /id="PRO_0000191806"
FT REGION 260..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 125..139
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 325..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 60698 MW; FA5802D275629D04 CRC64;
MADVLSVLRQ YNTQKKEIVV KGDEVIFGEF SWPKNVKTNY VIWGTGKEGQ PREYYTLDSI
LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLAYLNG ETSTSSSIDR SAPLEIGLQR
STQVKRAADE ILAEAKKPRI EDEECVRLDK ERLAARLEGH KEGIVQTEQI RSLSEAMSVE
KIAAIKAKIM AKKRSTIKTD LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS
TGKNFAKNIF AILQSVKARE EGRAPEQRPA PNTAPTDPTL RNKQPIPAAY NRYDQERFKG
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP PNQKKGSRTP
IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE NETLIQRRKD QMQPGGTTVS
VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY
DEVRLDPNVQ KWDVTVLELS YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F
