CDC73_SCHPO
ID CDC73_SCHPO Reviewed; 371 AA.
AC Q9UUE7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cell division control protein 73;
GN Name=cdc73; ORFNames=SPBC17G9.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: The PAF1 complex is a multifunctional complex. Involved in
CC transcription initiation via genetic interactions with TATA-binding
CC proteins. Involved in elongation. It regulates 3'-end formation of
CC snR47 by modulating the recruitment or stable association of nrd1 with
CC RNA polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the PAF1 complex which consists of at least
CC cdc73, paf1 and rtf1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the CDC73 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB52800.1; -; Genomic_DNA.
DR PIR; T39725; T39725.
DR RefSeq; NP_595891.1; NM_001021798.2.
DR AlphaFoldDB; Q9UUE7; -.
DR SMR; Q9UUE7; -.
DR BioGRID; 276174; 10.
DR STRING; 4896.SPBC17G9.02c.1; -.
DR MaxQB; Q9UUE7; -.
DR PaxDb; Q9UUE7; -.
DR PRIDE; Q9UUE7; -.
DR EnsemblFungi; SPBC17G9.02c.1; SPBC17G9.02c.1:pep; SPBC17G9.02c.
DR GeneID; 2539616; -.
DR KEGG; spo:SPBC17G9.02c; -.
DR PomBase; SPBC17G9.02c; cdc73.
DR VEuPathDB; FungiDB:SPBC17G9.02c; -.
DR eggNOG; KOG3786; Eukaryota.
DR HOGENOM; CLU_025849_2_0_1; -.
DR InParanoid; Q9UUE7; -.
DR OMA; GHTWQFN; -.
DR PhylomeDB; Q9UUE7; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-75955; RNA Polymerase II Transcription Elongation.
DR PRO; PR:Q9UUE7; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IPI:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0016570; P:histone modification; IEA:InterPro.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR Gene3D; 3.40.50.11990; -; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR PANTHER; PTHR12466; PTHR12466; 1.
DR Pfam; PF05179; CDC73_C; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..371
FT /note="Cell division control protein 73"
FT /id="PRO_0000339173"
SQ SEQUENCE 371 AA; 42629 MW; 44FF6D4E3E29B8E4 CRC64;
MDSLLLLKKS IAEKKDVKLL ASSEATSKVE KIEDAQYILF DENTSPILID EPTKFIKLEN
DSHFSLRSVY FAWLLRDTSI AEYIQQCSEL GIQNLTFLER TDLISWLEGS SDSEHIIGLE
KPKPEGSTDA ATSMDVDLHK KSEEVNWLFE NTRTVSNHNS VLHGIKPIDF ISLRKDVLDY
IHANKATASA HADEQERPAK KRNRDPIILL SPSASSLLTM HNIKKFLEEG IFVPPAEAAH
AAGGGRGPEL IALSHKSSNS KFGTMRFIIV EGTEKFKPDY WDRVVCVFTT GQAWQFRDYK
WSEPHQLFHH VKGFLVQYVG DPPHPATHDW NVEGIFVERL RRHTDREVVS QLWDKLERWM
ENRWPLWNGR R
