CDCA4_HUMAN
ID CDCA4_HUMAN Reviewed; 241 AA.
AC Q9BXL8; Q8TB18; Q9NWK7;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Cell division cycle-associated protein 4;
DE AltName: Full=Hematopoietic progenitor protein;
GN Name=CDCA4; Synonyms=HEPP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11482882; DOI=10.1006/bcmd.2001.0434;
RA Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.;
RT "Cloning and characterization of HEPP, a novel gene expressed
RT preferentially in hematopoietic progenitors and mature blood cells.";
RL Blood Cells Mol. Dis. 27:667-676(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-241.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16984923; DOI=10.1074/jbc.m603800200;
RA Hayashi R., Goto Y., Ikeda R., Yokoyama K.K., Yoshida K.;
RT "CDCA4 is an E2F transcription factor family-induced nuclear factor that
RT regulates E2F-dependent transcriptional activation and cell
RT proliferation.";
RL J. Biol. Chem. 281:35633-35648(2006).
CC -!- FUNCTION: May participate in the regulation of cell proliferation
CC through the E2F/RB pathway. May be involved in molecular regulation of
CC hematopoietic stem cells and progenitor cell lineage commitment and
CC differentiation (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:16984923}.
CC -!- INTERACTION:
CC Q9BXL8; Q13515: BFSP2; NbExp=3; IntAct=EBI-1773949, EBI-10229433;
CC Q9BXL8; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-1773949, EBI-8643161;
CC Q9BXL8; P02489: CRYAA; NbExp=3; IntAct=EBI-1773949, EBI-6875961;
CC Q9BXL8; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-1773949, EBI-744099;
CC Q9BXL8; P00488: F13A1; NbExp=3; IntAct=EBI-1773949, EBI-2565863;
CC Q9BXL8; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-1773949, EBI-2807642;
CC Q9BXL8; O95363: FARS2; NbExp=3; IntAct=EBI-1773949, EBI-2513774;
CC Q9BXL8; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-1773949, EBI-744935;
CC Q9BXL8; O60341: KDM1A; NbExp=2; IntAct=EBI-1773949, EBI-710124;
CC Q9BXL8; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-1773949, EBI-739890;
CC Q9BXL8; Q99732: LITAF; NbExp=3; IntAct=EBI-1773949, EBI-725647;
CC Q9BXL8; Q13064: MKRN3; NbExp=3; IntAct=EBI-1773949, EBI-2340269;
CC Q9BXL8; Q9BYG5: PARD6B; NbExp=3; IntAct=EBI-1773949, EBI-295391;
CC Q9BXL8; D3DTS7: PMP22; NbExp=3; IntAct=EBI-1773949, EBI-25882629;
CC Q9BXL8; Q96LA8: PRMT6; NbExp=2; IntAct=EBI-1773949, EBI-912440;
CC Q9BXL8; Q92529: SHC3; NbExp=3; IntAct=EBI-1773949, EBI-79084;
CC Q9BXL8; P51687: SUOX; NbExp=3; IntAct=EBI-1773949, EBI-3921347;
CC Q9BXL8; O43463: SUV39H1; NbExp=2; IntAct=EBI-1773949, EBI-349968;
CC Q9BXL8; Q9H5I1: SUV39H2; NbExp=2; IntAct=EBI-1773949, EBI-723127;
CC Q9BXL8; O15273: TCAP; NbExp=3; IntAct=EBI-1773949, EBI-954089;
CC Q9BXL8; Q99757: TXN2; NbExp=3; IntAct=EBI-1773949, EBI-2932492;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16984923}.
CC -!- TISSUE SPECIFICITY: Highest levels of expression in the pancreas,
CC thymus, testis, spleen, liver, placenta and leukocytes. Relatively low
CC levels in the lung, kidney, prostate, ovary, small intestine and colon.
CC Hardly detectable, if at all, in the brain, skeletal muscle and heart.
CC {ECO:0000269|PubMed:16984923}.
CC -!- INDUCTION: By E2F1. {ECO:0000269|PubMed:16984923}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91373.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF322239; AAK31075.1; -; mRNA.
DR EMBL; BC011736; AAH11736.1; -; mRNA.
DR EMBL; BC025263; AAH25263.1; -; mRNA.
DR EMBL; AK000771; BAA91373.1; ALT_INIT; mRNA.
DR CCDS; CCDS9996.1; -.
DR RefSeq; NP_060425.2; NM_017955.3.
DR RefSeq; NP_663747.1; NM_145701.2.
DR AlphaFoldDB; Q9BXL8; -.
DR BioGRID; 120367; 44.
DR IntAct; Q9BXL8; 38.
DR MINT; Q9BXL8; -.
DR STRING; 9606.ENSP00000337226; -.
DR iPTMnet; Q9BXL8; -.
DR PhosphoSitePlus; Q9BXL8; -.
DR BioMuta; CDCA4; -.
DR DMDM; 32699606; -.
DR EPD; Q9BXL8; -.
DR MassIVE; Q9BXL8; -.
DR MaxQB; Q9BXL8; -.
DR PaxDb; Q9BXL8; -.
DR PeptideAtlas; Q9BXL8; -.
DR PRIDE; Q9BXL8; -.
DR ProteomicsDB; 79451; -.
DR Antibodypedia; 28296; 204 antibodies from 27 providers.
DR DNASU; 55038; -.
DR Ensembl; ENST00000336219.4; ENSP00000337226.3; ENSG00000170779.11.
DR Ensembl; ENST00000392590.3; ENSP00000376369.3; ENSG00000170779.11.
DR GeneID; 55038; -.
DR KEGG; hsa:55038; -.
DR MANE-Select; ENST00000336219.4; ENSP00000337226.3; NM_017955.4; NP_060425.2.
DR UCSC; uc001yqa.3; human.
DR CTD; 55038; -.
DR DisGeNET; 55038; -.
DR GeneCards; CDCA4; -.
DR HGNC; HGNC:14625; CDCA4.
DR HPA; ENSG00000170779; Tissue enhanced (bone).
DR MIM; 612270; gene.
DR neXtProt; NX_Q9BXL8; -.
DR OpenTargets; ENSG00000170779; -.
DR PharmGKB; PA26277; -.
DR VEuPathDB; HostDB:ENSG00000170779; -.
DR eggNOG; ENOG502QWNU; Eukaryota.
DR GeneTree; ENSGT00530000063867; -.
DR HOGENOM; CLU_065586_1_0_1; -.
DR InParanoid; Q9BXL8; -.
DR OMA; QSSVWEM; -.
DR OrthoDB; 1511674at2759; -.
DR PhylomeDB; Q9BXL8; -.
DR TreeFam; TF101069; -.
DR PathwayCommons; Q9BXL8; -.
DR SignaLink; Q9BXL8; -.
DR BioGRID-ORCS; 55038; 13 hits in 1071 CRISPR screens.
DR ChiTaRS; CDCA4; human.
DR GenomeRNAi; 55038; -.
DR Pharos; Q9BXL8; Tbio.
DR PRO; PR:Q9BXL8; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9BXL8; protein.
DR Bgee; ENSG00000170779; Expressed in secondary oocyte and 165 other tissues.
DR ExpressionAtlas; Q9BXL8; baseline and differential.
DR Genevisible; Q9BXL8; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR InterPro; IPR009263; SERTA_dom.
DR Pfam; PF06031; SERTA; 1.
DR PROSITE; PS51053; SERTA; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..241
FT /note="Cell division cycle-associated protein 4"
FT /id="PRO_0000191617"
FT DOMAIN 30..77
FT /note="SERTA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT CONFLICT 93
FT /note="D -> N (in Ref. 2; AAH25263)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 241 AA; 26114 MW; 9693647E77865D7A CRC64;
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM LVEPNLCRSV
LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI LCRAAWGQEG AHPAPGLGDG
HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG PRENRGSFHK SLDQIFETLE TKNPSCMEEL
FSDVDSPYYD LDTVLTGMMG GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE
T
