ID   CDCA4_MOUSE             Reviewed;         237 AA.
AC   Q9CWM2; Q3U1C0; Q921E8; Q99MP6;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Cell division cycle-associated protein 4;
DE   AltName: Full=Hematopoietic progenitor protein;
GN   Name=Cdca4; Synonyms=Hepp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX   PubMed=11482882; DOI=10.1006/bcmd.2001.0434;
RA   Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.;
RT   "Cloning and characterization of HEPP, a novel gene expressed
RT   preferentially in hematopoietic progenitors and mature blood cells.";
RL   Blood Cells Mol. Dis. 27:667-676(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Mesonephros, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May participate in the regulation of cell proliferation
CC       through the E2F/RB pathway (By similarity). May be involved in
CC       molecular regulation of hematopoietic stem cells and progenitor cell
CC       lineage commitment and differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed preferentially in hematopoietic
CC       progenitors and mature blood cells. Expressed at low levels in the
CC       heart, lung, spleen, and thymus and at a higher level in muscle.
CC   -!- DEVELOPMENTAL STAGE: Developmentally regulated. Preferential expression
CC       in both fetal and adult hematopoietic progenitors and mature blood
CC       cells during embryonic and adult hematopoiesis.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH12953.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK010535; BAB27012.2; -; mRNA.
DR   EMBL; AK156081; BAE33578.1; -; mRNA.
DR   EMBL; AF322238; AAK31074.1; -; mRNA.
DR   EMBL; AK032980; BAC28109.1; -; mRNA.
DR   EMBL; BC012953; AAH12953.1; ALT_INIT; mRNA.
DR   EMBL; BC055824; AAH55824.1; -; mRNA.
DR   CCDS; CCDS26198.1; -.
DR   RefSeq; NP_082299.1; NM_028023.3.
DR   RefSeq; XP_006516307.1; XM_006516244.1.
DR   AlphaFoldDB; Q9CWM2; -.
DR   STRING; 10090.ENSMUSP00000058901; -.
DR   PhosphoSitePlus; Q9CWM2; -.
DR   MaxQB; Q9CWM2; -.
DR   PaxDb; Q9CWM2; -.
DR   PRIDE; Q9CWM2; -.
DR   ProteomicsDB; 283767; -.
DR   Antibodypedia; 28296; 204 antibodies from 27 providers.
DR   DNASU; 71963; -.
DR   Ensembl; ENSMUST00000062092; ENSMUSP00000058901; ENSMUSG00000047832.
DR   Ensembl; ENSMUST00000220899; ENSMUSP00000152315; ENSMUSG00000047832.
DR   GeneID; 71963; -.
DR   KEGG; mmu:71963; -.
DR   UCSC; uc007pfi.1; mouse.
DR   CTD; 55038; -.
DR   MGI; MGI:1919213; Cdca4.
DR   VEuPathDB; HostDB:ENSMUSG00000047832; -.
DR   eggNOG; ENOG502QWNU; Eukaryota.
DR   GeneTree; ENSGT00530000063867; -.
DR   HOGENOM; CLU_065586_1_0_1; -.
DR   InParanoid; Q9CWM2; -.
DR   OMA; QSSVWEM; -.
DR   OrthoDB; 1511674at2759; -.
DR   PhylomeDB; Q9CWM2; -.
DR   TreeFam; TF101069; -.
DR   BioGRID-ORCS; 71963; 4 hits in 75 CRISPR screens.
DR   ChiTaRS; Cdca4; mouse.
DR   PRO; PR:Q9CWM2; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q9CWM2; protein.
DR   Bgee; ENSMUSG00000047832; Expressed in presomitic mesoderm and 266 other tissues.
DR   Genevisible; Q9CWM2; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   InterPro; IPR009263; SERTA_dom.
DR   Pfam; PF06031; SERTA; 1.
DR   PROSITE; PS51053; SERTA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..237
FT                   /note="Cell division cycle-associated protein 4"
FT                   /id="PRO_0000191618"
FT   DOMAIN          26..73
FT                   /note="SERTA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00396"
FT   CONFLICT        196
FT                   /note="S -> T (in Ref. 3; AAH12953)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        213
FT                   /note="T -> A (in Ref. 3; AAH12953)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   237 AA;  26107 MW;  52EC046EFDDF326E CRC64;
     MFARGLKRKY GDQEEGVEGF GTVPSYSLQR QSLLDMSLVK LQLCHMLVEP NLCRSVLIAN
     TVRQIQEEMS QDGVWHGMAP QNVDRAPVER LVSTEILCRT VRGAEEEHPA PELEDAPLQN
     SVSELPIVGS APGQRNPQSS LWEMDSPQEN RGSFQKSLDQ IFETLENKNS SSVEELFSDV
     DSSYYDLDTV LTGMMSGTKS SLCNGLEGFA AATPPPSSTC KSDLAELDHV VEILVET