CDCP2_HUMAN
ID CDCP2_HUMAN Reviewed; 449 AA.
AC Q5VXM1; Q6ZWJ3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=CUB domain-containing protein 2;
DE Flags: Precursor;
GN Name=CDCP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VXM1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VXM1-2; Sequence=VSP_028212, VSP_028213;
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DR EMBL; AK122760; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL357673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS588.2; -. [Q5VXM1-1]
DR RefSeq; NP_963840.2; NM_201546.3. [Q5VXM1-1]
DR AlphaFoldDB; Q5VXM1; -.
DR SMR; Q5VXM1; -.
DR BioGRID; 128289; 66.
DR STRING; 9606.ENSP00000360381; -.
DR GlyGen; Q5VXM1; 2 sites.
DR BioMuta; CDCP2; -.
DR DMDM; 74747554; -.
DR PaxDb; Q5VXM1; -.
DR PeptideAtlas; Q5VXM1; -.
DR PRIDE; Q5VXM1; -.
DR Antibodypedia; 33162; 15 antibodies from 9 providers.
DR DNASU; 200008; -.
DR Ensembl; ENST00000371330.1; ENSP00000360381.1; ENSG00000157211.11. [Q5VXM1-1]
DR GeneID; 200008; -.
DR KEGG; hsa:200008; -.
DR UCSC; uc001cwv.3; human. [Q5VXM1-1]
DR CTD; 200008; -.
DR DisGeNET; 200008; -.
DR GeneCards; CDCP2; -.
DR HGNC; HGNC:27297; CDCP2.
DR HPA; ENSG00000157211; Not detected.
DR MIM; 612320; gene.
DR neXtProt; NX_Q5VXM1; -.
DR OpenTargets; ENSG00000157211; -.
DR PharmGKB; PA143485432; -.
DR VEuPathDB; HostDB:ENSG00000157211; -.
DR eggNOG; ENOG502QVE6; Eukaryota.
DR GeneTree; ENSGT00940000158291; -.
DR HOGENOM; CLU_015228_7_1_1; -.
DR InParanoid; Q5VXM1; -.
DR OMA; HCHWTIR; -.
DR OrthoDB; 4105at2759; -.
DR PhylomeDB; Q5VXM1; -.
DR TreeFam; TF316506; -.
DR PathwayCommons; Q5VXM1; -.
DR BioGRID-ORCS; 200008; 14 hits in 1059 CRISPR screens.
DR ChiTaRS; CDCP2; human.
DR GenomeRNAi; 200008; -.
DR Pharos; Q5VXM1; Tdark.
DR PRO; PR:Q5VXM1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VXM1; protein.
DR Bgee; ENSG00000157211; Expressed in granulocyte and 14 other tissues.
DR ExpressionAtlas; Q5VXM1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; -; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR Pfam; PF00431; CUB; 3.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF49854; SSF49854; 3.
DR PROSITE; PS01180; CUB; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..449
FT /note="CUB domain-containing protein 2"
FT /id="PRO_0000305071"
FT DOMAIN 30..143
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 145..255
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 257..373
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT REGION 381..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 30..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 83..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 145..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 198..218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 257..283
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 314..336
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT VAR_SEQ 143..157
FT /note="DVCGGVLTGLSGVLT -> GQRGALGTCCSGSHL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028212"
FT VAR_SEQ 158..449
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028213"
FT VARIANT 244
FT /note="G -> R (in dbSNP:rs3766465)"
FT /id="VAR_035162"
SQ SEQUENCE 449 AA; 48752 MW; D3C3063A0D17E6C7 CRC64;
MLAEWGACLL LAVALLGPGL QAQAMEGVKC GGVLSAPSGN FSSPNFPRLY PYNTECSWLI
VVAEGSSVLL TFHAFDLEYH DTCSFDFLEI YNGASPDKGN LLGRFCGKVP PPPFTSSWHV
MSVIFHSDKH VASHGFSAGY QKDVCGGVLT GLSGVLTSPE YPNNYPNSME CHWVIRAAGP
AHVKLVFVDF QVEGNEECTY DYVAVLGGPG PTRGHHYCGS TRPPTLVSLG HELQVVFKSD
FNIGGRGFKA YYFSGECQEV YMAMRGNFSS PQYPSSYPNN IRCHWTIRLP PGYQVKVFFL
DLDLEEPNSL TKTCDFDHLA AFDGASEEAP LLGNWCGHHL PPPVTSSHNQ LLLLLHTDRS
TTRRGFSVAY IGGQLGCGSG STEGEGEALQ PQSLQSPSSI PPVCPAPPMN GLLQLLLHWL
HPCPLSGPLR LDGTAPACFH YCRASFPSF
