CDCP2_MOUSE
ID CDCP2_MOUSE Reviewed; 427 AA.
AC Q8BQH6;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=CUB domain-containing protein 2;
DE Flags: Precursor;
GN Name=Cdcp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK050720; BAC34392.1; -; mRNA.
DR EMBL; AL607132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18430.1; -.
DR RefSeq; NP_766461.1; NM_172873.3.
DR AlphaFoldDB; Q8BQH6; -.
DR SMR; Q8BQH6; -.
DR STRING; 10090.ENSMUSP00000061401; -.
DR GlyGen; Q8BQH6; 2 sites.
DR PaxDb; Q8BQH6; -.
DR PRIDE; Q8BQH6; -.
DR Antibodypedia; 33162; 15 antibodies from 9 providers.
DR DNASU; 242603; -.
DR Ensembl; ENSMUST00000062495; ENSMUSP00000061401; ENSMUSG00000047636.
DR GeneID; 242603; -.
DR KEGG; mmu:242603; -.
DR UCSC; uc008tzf.1; mouse.
DR CTD; 200008; -.
DR MGI; MGI:3045328; Cdcp2.
DR VEuPathDB; HostDB:ENSMUSG00000047636; -.
DR eggNOG; ENOG502QVE6; Eukaryota.
DR GeneTree; ENSGT00940000158291; -.
DR HOGENOM; CLU_015228_7_1_1; -.
DR InParanoid; Q8BQH6; -.
DR OMA; HCHWTIR; -.
DR OrthoDB; 4105at2759; -.
DR PhylomeDB; Q8BQH6; -.
DR TreeFam; TF316506; -.
DR BioGRID-ORCS; 242603; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BQH6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BQH6; protein.
DR Bgee; ENSMUSG00000047636; Expressed in embryonic post-anal tail and 1 other tissue.
DR ExpressionAtlas; Q8BQH6; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; -; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR Pfam; PF00431; CUB; 3.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF49854; SSF49854; 3.
DR PROSITE; PS01180; CUB; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..427
FT /note="CUB domain-containing protein 2"
FT /id="PRO_0000305072"
FT DOMAIN 30..143
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 145..255
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 257..373
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 30..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 83..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 145..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 198..218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 257..283
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 314..336
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 427 AA; 46319 MW; 9F496276F736BB28 CRC64;
MLAELGACLL LAMVLLDSDP GTQAMEGVKC GGVLSAPSGN FSSPNFPSLY PYNTECSWLI
VVAEGSSVLL TFHAFDLEYH DTCGFDFLEI YNGASGDKGN LLGRFCGQVP PPPFTSSWHV
MSVVFHSDKH VASRGFSAGY QKDVCGGVLT GLSGVLSSPE YPNNYPNNVE CHWLIRASGP
AAVKLVFVDF QVEGSDECMY DYVAVLGAPG PAHGHHYCGR TRPPTFVSLG HELQVVFKSD
FNIGGRGFKA HYFSGECQEV FTAVRGNFSS PQYPGAYPNN IRCHWTIRLP PGYRVKVFIL
DLGLEEPNSL TRTCDFDHLA AFDGASEEAQ LLGKWCGHHL PPPVTSSRNQ VLLLLHTDRS
TSGRGFSVAY IGGQLGVCPW ELCGPFLCPL RHSPSTDSSR PHSVAYPGDL GGHSSTALIY
FHCHLFS
