ID   CDGB_TREDE              Reviewed;         314 AA.
AC   Q73R77;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Cyclic di-GMP binding protein TDE_0214;
GN   OrderedLocusNames=TDE_0214;
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G.,
RA   Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K.,
RA   Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E.,
RA   Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
RN   [2]
RP   FUNCTION, C-DI-GMP-BINDING, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX   PubMed=23794624; DOI=10.1128/jb.00610-13;
RA   Bian J., Liu X., Cheng Y.Q., Li C.;
RT   "Inactivation of cyclic Di-GMP binding protein TDE0214 affects the
RT   motility, biofilm formation, and virulence of Treponema denticola.";
RL   J. Bacteriol. 195:3897-3905(2013).
CC   -!- FUNCTION: Cyclic-di-GMP binding protein that plays important roles in
CC       motility, chemotaxis, biofilm formation and virulence.
CC       {ECO:0000269|PubMed:23794624}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are less motile, reverse more frequently
CC       than the wild-type cells, and form less biofilm. Invasiveness and
CC       ability to induce skin abscesses and host humoral immune responses are
CC       significantly attenuated. {ECO:0000269|PubMed:23794624}.
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DR   EMBL; AE017226; AAS10711.1; -; Genomic_DNA.
DR   RefSeq; NP_970830.1; NC_002967.9.
DR   RefSeq; WP_002681114.1; NC_002967.9.
DR   AlphaFoldDB; Q73R77; -.
DR   SMR; Q73R77; -.
DR   STRING; 243275.TDE_0214; -.
DR   EnsemblBacteria; AAS10711; AAS10711; TDE_0214.
DR   GeneID; 2739371; -.
DR   KEGG; tde:TDE_0214; -.
DR   PATRIC; fig|243275.7.peg.208; -.
DR   eggNOG; ENOG502ZPJT; Bacteria.
DR   HOGENOM; CLU_070336_0_0_12; -.
DR   OMA; MMGVAKF; -.
DR   OrthoDB; 907046at2; -.
DR   PHI-base; PHI:4141; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0035438; F:cyclic-di-GMP binding; IEA:InterPro.
DR   InterPro; IPR009875; PilZ_domain.
DR   Pfam; PF07238; PilZ; 1.
PE   1: Evidence at protein level;
KW   c-di-GMP; Reference proteome.
FT   CHAIN           1..314
FT                   /note="Cyclic di-GMP binding protein TDE_0214"
FT                   /id="PRO_0000429753"
FT   DOMAIN          146..234
FT                   /note="PilZ"
FT   REGION          288..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34811 MW;  3E84CE5DFB3D0921 CRC64;
     MAFAASQQLN RYYNLYKNID VTFSKEVVST LNFEPKQVFV RCSGGQWPCI INSASMTKAK
     IICGKKSGFL ARLRSGITSV NIRFAFFDTE GKDSLSFFVA AKLVGISSYE AGNQDLVLIT
     FEYTQRAPDD LIEKLGILLE ANINSQKRRN ERVVITPEIS RKIGLVEKGT VVYIDAVPRR
     CLIRDLSFSG AKILLVGIAN FLINKEVILR FAFDDPQSVF GIKGKTVRTE PVEGRKDLVA
     LAVQYYPKNI PMMYKMYLNK YFSVVRKPAS DGFGDDFLED VAPASSFTPV SSPIGTNTAP
     LTPPPADSAP EQIS