ID   CDHR1_CHICK             Reviewed;         865 AA.
AC   Q8UVJ7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Cadherin-related family member 1;
DE   AltName: Full=Photoreceptor cadherin;
DE            Short=prCAD;
DE   AltName: Full=Protocadherin-21;
DE   Flags: Precursor;
GN   Name=CDHR1; Synonyms=PCDH21, PRCAD;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11738025; DOI=10.1016/s0896-6273(01)00531-1;
RA   Rattner A., Smallwood P.M., Williams J., Cooke C., Savchenko A.,
RA   Lyubarsky A., Pugh E.N., Nathans J.;
RT   "A photoreceptor-specific cadherin is essential for the structural
RT   integrity of the outer segment and for photoreceptor survival.";
RL   Neuron 32:775-786(2001).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AF426394; AAL65141.1; -; mRNA.
DR   RefSeq; NP_001001759.1; NM_001001759.1.
DR   AlphaFoldDB; Q8UVJ7; -.
DR   SMR; Q8UVJ7; -.
DR   STRING; 9031.ENSGALP00000040376; -.
DR   PaxDb; Q8UVJ7; -.
DR   GeneID; 414847; -.
DR   KEGG; gga:414847; -.
DR   CTD; 92211; -.
DR   VEuPathDB; HostDB:geneid_414847; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   InParanoid; Q8UVJ7; -.
DR   OrthoDB; 237790at2759; -.
DR   PhylomeDB; Q8UVJ7; -.
DR   PRO; PR:Q8UVJ7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Membrane; Receptor; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..865
FT                   /note="Cadherin-related family member 1"
FT                   /id="PRO_0000318501"
FT   TOPO_DOM        24..705
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        706..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        727..865
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          38..137
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          138..249
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          250..356
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          362..475
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          476..579
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          571..690
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   REGION          782..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        793..807
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   865 AA;  95256 MW;  B540C82B6D7F6384 CRC64;
     MKHVRHFIPS LFLSLVHVCL VQANYAPYFF DNGARSTNGN MALLSLSEDT PVGSHVYTLN
     GTDPEGDPVT YGLTYEAGSR RYFSVDGNLG NVTLIEELDR EKEDEIEVIV SISDGLSTVS
     EKVRILVMDA NDESPEFINT PYIVQVPENS PSGSSIFKIE AVDRDTGSGG SITYFLQNIH
     ANKFTIDRHS GVLRIKSGVT LDYEKSRTHF VVVVAKDGGG KLRGDNKVFS ATTTVTVNVE
     DVQDTPPMFI GTPYYGYVYE DTLPGSEVLT VVALDGDRGK PNNIHYCIVN GSEGSFEISN
     TTGAISVIKS PNQLKKEVYE LRVQASEVSP EGDVSAYAFA TVTIRVVDLN NHPPTFYGES
     GPQNRFELTM YEHPPEGEIL RGLKITVNDS DQGANAKFNL RLVGPGGIFR VVPLTVLNEA
     QVTIIVENSA AIDYEKFKVL TFKLLAIEVN TPEKFSSTAD IAIRLLDTND NVPKFSSDYY
     IARIPENSPG GSNVVAVTAT DPDSGLWGEV KYSIYGTGAD LFLIHPSTGI IYTQPWAVLD
     AEVNSKYNFY VKAEDTDGKY SLAEVFITVL DVNDHSPEFN ENIQEKTMII GSPVKIEAID
     QDAEEPNNIV DYSIMQADPA NVFDIDQSTG EIKLKSYIRS LDIIHNITKN KDCIWSLVVQ
     AKDRGSPSFS TTAVLKIDIT EETLHKGPMA AFLMQTKDNP MKALGVLAGV MGIMVLITIM
     ISTAMFWRNK RSNKIMPVRR IIKKRQTQQS RTVRMEWLKF KRPSNAAEKF VVEDDAKSLQ
     NENSNNNVQA APVPPAAPLP PPPPALAASG NTTAWRVPTV SGSLTPKFIN KQLKKRGHSS
     THNALVSELK MKFEKRNASM GEPHI