ID   CDHR1_DANRE             Reviewed;         857 AA.
AC   Q6B3P0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Cadherin-related family member 1;
DE   AltName: Full=Photoreceptor cadherin;
DE            Short=prCAD;
DE   AltName: Full=Protocadherin-21;
DE   Flags: Precursor;
GN   Name=cdhr1; Synonyms=pcdh21, prcad;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX   PubMed=15284225; DOI=10.1074/jbc.m407928200;
RA   Rattner A., Chen J., Nathans J.;
RT   "Proteolytic shedding of the extracellular domain of photoreceptor
RT   cadherin. Implications for outer segment assembly.";
RL   J. Biol. Chem. 279:42202-42210(2004).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in photoreceptor cells of the outer
CC       nuclear layer of the retina and in the pinal gland.
CC       {ECO:0000269|PubMed:15284225}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the retina 4 days post-fertilization
CC       (hpf). {ECO:0000269|PubMed:15284225}.
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DR   EMBL; AY684930; AAT92537.1; -; mRNA.
DR   RefSeq; NP_001005402.1; NM_001005402.1.
DR   AlphaFoldDB; Q6B3P0; -.
DR   SMR; Q6B3P0; -.
DR   STRING; 7955.ENSDARP00000101442; -.
DR   PaxDb; Q6B3P0; -.
DR   Ensembl; ENSDART00000110005; ENSDARP00000101442; ENSDARG00000004643.
DR   GeneID; 449008; -.
DR   KEGG; dre:449008; -.
DR   CTD; 449008; -.
DR   ZFIN; ZDB-GENE-040924-4; cdhr1a.
DR   eggNOG; KOG3594; Eukaryota.
DR   GeneTree; ENSGT00940000155509; -.
DR   HOGENOM; CLU_017357_0_0_1; -.
DR   InParanoid; Q6B3P0; -.
DR   OMA; KILYICS; -.
DR   OrthoDB; 237790at2759; -.
DR   PhylomeDB; Q6B3P0; -.
DR   TreeFam; TF332908; -.
DR   PRO; PR:Q6B3P0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000004643; Expressed in retina and 9 other tissues.
DR   ExpressionAtlas; Q6B3P0; baseline.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   Pfam; PF00028; Cadherin; 4.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Membrane; Receptor; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..857
FT                   /note="Cadherin-related family member 1"
FT                   /id="PRO_0000318502"
FT   TOPO_DOM        26..709
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        710..730
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        731..857
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          40..139
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          140..252
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          253..359
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          365..478
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          479..582
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          574..693
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   REGION          746..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        750..765
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   857 AA;  95169 MW;  4E5CCADACB280215 CRC64;
     MKNAREIQFS SFLLLAHFCF VGAQSDYAPY FYDNGPNSNN GNMALLNLSE DTPRGTQIYV
     LNGTDPEGQP VKYGITFEPG SKEFFRVHPK SGVVTLIEDL DREAQDEIEV FVSISDSLNK
     VVEKVSVFIM DANDERPQFQ NMPSIVDVPE NTTSGSSIYK VQAVDRDTGS GGSVTYFLQS
     SEQSPKFAID HHSGVLRIKP GESLDYEKSR THFITVVAKD GGGIYKGKQQ VMSSSATLTI
     NVIDTQDSPP IFIGTPYFGY VYEVSSPGSE IFTVSAKDGD MDNPNTIIYS LDSGADGSFS
     INKTSGVITL NLYPADLRRE VFNIKVKALE ISPEGKRLDF ATTTVTIRVV DLNNHPPTFY
     GENGPQNVFE LTMYEHPQEG EFLRGLKITV NDSDQGSNAK FNLRLVGPGR MLRVVPQTVL
     NEAQVTVLVE DSAAMDFEKS QFLTFKLLAV EIDTPERFSA TADIIIHLLD TNDNAPKFTS
     DFYIARIPEN SPGGSNVVSV TAMDPDSGIW GVVKYSIYGS GADIFLIQAD SGIIYTQPWA
     SLDAEVKSKY NFYVKAEDPE GKYSLAEVFV TITDLNDHPP AFNENSLEQT MVIGAPVKIE
     AIDEDAEEPN NLIEYSIMKA DPDNIFDINA DTGEIKLKPY IKSMDIVQNI TNQRDCTWSV
     VVQAKDRGSP SFSTTTVVKI DITEATPLKG PLTSFFMNSR ENPMHFLGLI SGVILILVFV
     TVIISTVIFV RRNKANRILP SRRIIRKKRK PQKQDDFQEP FREEQEIPRA DNVNFNNNIK
     VCSHRTPPSP PNAPVMPPPL PSHCRHGERE WTVPTVSASV ASKSKKKSHR CKDNPVNTAL
     VSELKLKLEQ KNMANRY