CDHR1_RAT
ID CDHR1_RAT Reviewed; 859 AA.
AC Q91XU7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cadherin-related family member 1;
DE AltName: Full=MT-protocadherin;
DE AltName: Full=Photoreceptor cadherin;
DE Short=prCAD;
DE AltName: Full=Protocadherin-21;
DE Flags: Precursor;
GN Name=Cdhr1; Synonyms=Kiaa1775, Pcdh21, Prcad;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Olfactory bulb;
RX PubMed=11597768; DOI=10.1016/s0169-328x(01)00218-2;
RA Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.;
RT "Identification of three novel non-classical cadherin genes through
RT comprehensive analysis of large cDNAs.";
RL Brain Res. Mol. Brain Res. 94:85-95(2001).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=11738025; DOI=10.1016/s0896-6273(01)00531-1;
RA Rattner A., Smallwood P.M., Williams J., Cooke C., Savchenko A.,
RA Lyubarsky A., Pugh E.N., Nathans J.;
RT "A photoreceptor-specific cadherin is essential for the structural
RT integrity of the outer segment and for photoreceptor survival.";
RL Neuron 32:775-786(2001).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC required for the structural integrity of the outer segment (OS) of
CC photoreceptor cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PROM1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}. Note=Localized at the junction between the inner
CC and outer segments of rod and cone photoreceptors cells. Confined to
CC the base of the OS. Localized on the edges of nascent evaginating disks
CC on the side of the OS opposite the connecting cilium. Expressed at
CC postnatal day 2 at the apical tip of the rod photoreceptor cells, the
CC site of the developing OS. Colocalized with rhodopsin between postnatal
CC days 2 and 9 at the base of the growing OS region (By similarity).
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the retina. Strongly expressed by the
CC mitral and tufted cells in the main and accessory olfactory bulbs. Also
CC expressed in the septum and olfactory cortex. Weakly expressed in the
CC triangular septal nucleus and piriform cortex.
CC {ECO:0000269|PubMed:11597768, ECO:0000269|PubMed:11738025}.
CC -!- PTM: Undergoes proteolytic cleavage; produces a soluble 95 kDa N-
CC terminal fragment and a 25 kDa cell-associated C-terminal fragment.
CC {ECO:0000250}.
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DR EMBL; AB053449; BAB61906.1; -; mRNA.
DR RefSeq; NP_446024.1; NM_053572.1.
DR AlphaFoldDB; Q91XU7; -.
DR SMR; Q91XU7; -.
DR STRING; 10116.ENSRNOP00000018631; -.
DR GlyGen; Q91XU7; 4 sites.
DR PaxDb; Q91XU7; -.
DR GeneID; 93662; -.
DR KEGG; rno:93662; -.
DR UCSC; RGD:620420; rat.
DR CTD; 92211; -.
DR RGD; 620420; Cdhr1.
DR VEuPathDB; HostDB:ENSRNOG00000013330; -.
DR eggNOG; KOG3594; Eukaryota.
DR HOGENOM; CLU_017357_0_0_1; -.
DR InParanoid; Q91XU7; -.
DR OMA; EAPQFIN; -.
DR OrthoDB; 237790at2759; -.
DR PhylomeDB; Q91XU7; -.
DR PRO; PR:Q91XU7; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000013330; Expressed in thymus and 10 other tissues.
DR Genevisible; Q91XU7; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0045494; P:photoreceptor cell maintenance; ISO:RGD.
DR GO; GO:0008594; P:photoreceptor cell morphogenesis; ISO:RGD.
DR GO; GO:0035845; P:photoreceptor cell outer segment organization; ISO:RGD.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..859
FT /note="Cadherin-related family member 1"
FT /id="PRO_0000318500"
FT TOPO_DOM 22..701
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 702..722
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 723..859
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..135
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 136..247
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 248..354
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 360..473
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 474..577
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 569..691
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 789..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 859 AA; 93764 MW; 84FDB78609901C9B CRC64;
MRRGPQVALV LGLLCIYLAQ ANFAPHFFDN GVGSTNGNMA LFSLPEDTPV GSHVYTLNGT
DPEGDPISYH ISFDPSTRSV FSVDPNFGNI TLVEELDRER EDEIEAIISI SDGLNLVAEK
VVIVVTDAND EAPRFLQEPY NILVPENTPA GSSIFKVQAE DKDTGSGGSV TYFLQSLHSS
KFTVDRHSGV LRLQAGATLD YEKSRAHFIT VVAKDGGGRL RGADVVFSAT TTVTINVEDV
QDTAPIFVGT PYYGYVYEDT LPGSEVLTVV AIDGDRGKPN HILYRLLNES DGLFEINETS
GAISVLQSPA QLRREVYELH VQVTEVNSSG SPAAQSTVPV IIRIVDLNNH PPTFYGESGP
QNKFELSMFE HPPQGEILRG LKITVNDSDQ GANAKFNLRL VGPGGIFRVV PQTVLNEAQV
TIIVENSAAI DFEKSKSLTF KLLAIEVNTP EKFSSTADIV IQLLDTNDNV PKFTSHYYIA
RIPENVPGGS NVVAVTAVDP DTGPWGKVQY SIYGTGSDLF LIHPSTGLIY TQPWASLDAE
GTSRYNFYVK AEDMDGRYSL AEVFVTLLDV NDHYPQFVQS VQEKTMVLGT PLKIEATDQD
AEEPNNLVDY SITRAEPVNV FDIDAHTGEI RLKNSIRSLE ALHNITPSGE YSWSLQVQAK
DRGSPSFSTT ALLKIDITDT ERLSRSSMAA FLIQTKDNPM KAVGVLAGVM AIVVAITVLI
STATFWRNKK SNKVLPVRRV LRRRPSPAPH TVRIEWLKFR RAKAASKFIL KEDPPNENCN
NSRVGVTVPP RAPALPPPPK MASSTVAQQT VPTVSGSLTP QPSQQLPTPK PLGGPAQSSL
VSELKQKFEK KSLGNKAYV
