CDHR3_MOUSE
ID CDHR3_MOUSE Reviewed; 831 AA.
AC Q8BL00; B2RSL6;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Cadherin-related family member 3;
DE AltName: Full=Cadherin-like protein 28;
DE Flags: Precursor;
GN Name=Cdhr3; Synonyms=Cdh28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZTQ4};
CC Single-pass type I membrane protein {ECO:0000250}.
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DR EMBL; AK047666; BAC33118.1; -; mRNA.
DR EMBL; AK049806; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC138911; AAI38912.1; -; mRNA.
DR CCDS; CCDS36430.1; -.
DR RefSeq; NP_001019649.1; NM_001024478.1.
DR RefSeq; XP_006515253.1; XM_006515190.3.
DR AlphaFoldDB; Q8BL00; -.
DR SMR; Q8BL00; -.
DR STRING; 10090.ENSMUSP00000093449; -.
DR GlyGen; Q8BL00; 3 sites.
DR iPTMnet; Q8BL00; -.
DR PhosphoSitePlus; Q8BL00; -.
DR PaxDb; Q8BL00; -.
DR PRIDE; Q8BL00; -.
DR ProteomicsDB; 281516; -.
DR Antibodypedia; 2413; 65 antibodies from 16 providers.
DR DNASU; 68764; -.
DR Ensembl; ENSMUST00000095774; ENSMUSP00000093449; ENSMUSG00000035860.
DR GeneID; 68764; -.
DR KEGG; mmu:68764; -.
DR UCSC; uc007nij.1; mouse.
DR CTD; 222256; -.
DR MGI; MGI:1916014; Cdhr3.
DR VEuPathDB; HostDB:ENSMUSG00000035860; -.
DR eggNOG; KOG3594; Eukaryota.
DR eggNOG; KOG4289; Eukaryota.
DR GeneTree; ENSGT00940000161245; -.
DR HOGENOM; CLU_017741_0_0_1; -.
DR InParanoid; Q8BL00; -.
DR OMA; AGHKSFH; -.
DR OrthoDB; 592155at2759; -.
DR PhylomeDB; Q8BL00; -.
DR TreeFam; TF336601; -.
DR BioGRID-ORCS; 68764; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BL00; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BL00; protein.
DR Bgee; ENSMUSG00000035860; Expressed in olfactory epithelium and 39 other tissues.
DR Genevisible; Q8BL00; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR Pfam; PF00028; Cadherin; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; SSF49313; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..831
FT /note="Cadherin-related family member 3"
FT /id="PRO_0000305904"
FT TOPO_DOM 20..711
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 733..831
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..132
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 136..236
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 237..344
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 346..466
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 462..570
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 567..693
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 743..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 831 AA; 92084 MW; 989B3DAFCEAAFCAB CRC64;
MQGAVIVLVL FGITSGGEAL HLLHLPATSN VAENAPPATL VHKFSVNLSV SLSPVIPGFP
LVVNPRPFTE AFRVNRLSAT NFEVVTTGKE QLDFERGPKA FDLQIYVKDD VGVTDVQVLT
VQVTDVNEPP QFQGILAQGL NLYVIERTNP GFIYQVEAFD PEDTSRSIPL GYFLISPSKN
FRMSANGTLF STTELDFEAG HKSFNLLVGV RDSGNLEAST ALQVTIVNIN DETPRFTSPR
RVYSVPEEVP LGTMVANITA MDPDDEGFPG RLLYSITTTS SYFMVDQLTG TIQVARRLDR
DAGELRQNPI ISLEVRVRDR PSGGQENRMQ ITFIVEDIND NPATCRKLTF SIMLPERTAN
GTLLLDLNKF CFDDDSEAPN NKFNFTTPSG AGSSRRFSQH PAGSGRIVLT GDLDYENPSN
LAVGNVYNVM IQVQDAAPPY YKKSIYISIL TRPENEFPLI FERPSYVFDV PERRPARTQI
GQVRATDADF PRTPVVYSVS RGGSSLQYPN IFWINPKTGE LQLITQADHE TTSVYILTVE
ATNGEDRSSV TVTVNILGEN DEKPVCTPNF YFMAIPVDLK VGTNIQNFKL TCTDLDSSPS
SFRYSIGSGN INNHFTFSPN AGSNITRLLL ASRFDYSSLD TVWDYQLLVH ITDDNLLSGS
TKAKALVETG TVTLSVKVIP HPTTTITTPR PRITYQIRRE NVYSTSAWYV PFIVTLGSIL
LLGLLGSLMV LLSKAVYRHC SSTTRRDRKP LTKKRDTKRM NREAMVESIQ MNSVFDGEAV
DPVTGEIYEF NSKTGARRWK GPLTQLPNWP EPSTQHRGTA GEAPVPKHTG R
