CDHR4_HUMAN
ID CDHR4_HUMAN Reviewed; 788 AA.
AC A6H8M9; Q6UXT0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Cadherin-related family member 4;
DE AltName: Full=Cadherin-like protein 29;
DE Flags: Precursor;
GN Name=CDHR4; Synonyms=CDH29; ORFNames=UNQ9392/PRO34300;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6H8M9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H8M9-2; Sequence=VSP_031552, VSP_031553;
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DR EMBL; AY358221; AAQ88588.1; -; mRNA.
DR EMBL; BC132756; AAI32757.1; -; mRNA.
DR EMBL; BC146674; AAI46675.1; -; mRNA.
DR CCDS; CCDS46829.1; -. [A6H8M9-1]
DR RefSeq; NP_001007541.2; NM_001007540.3. [A6H8M9-1]
DR AlphaFoldDB; A6H8M9; -.
DR SMR; A6H8M9; -.
DR BioGRID; 132983; 94.
DR STRING; 9606.ENSP00000391409; -.
DR GlyGen; A6H8M9; 1 site.
DR iPTMnet; A6H8M9; -.
DR PhosphoSitePlus; A6H8M9; -.
DR BioMuta; CDHR4; -.
DR MassIVE; A6H8M9; -.
DR PaxDb; A6H8M9; -.
DR PeptideAtlas; A6H8M9; -.
DR PRIDE; A6H8M9; -.
DR ProteomicsDB; 775; -. [A6H8M9-1]
DR Antibodypedia; 49593; 26 antibodies from 8 providers.
DR DNASU; 389118; -.
DR Ensembl; ENST00000343366.8; ENSP00000341302.4; ENSG00000187492.9. [A6H8M9-2]
DR Ensembl; ENST00000412678.7; ENSP00000391409.2; ENSG00000187492.9. [A6H8M9-1]
DR GeneID; 389118; -.
DR KEGG; hsa:389118; -.
DR MANE-Select; ENST00000412678.7; ENSP00000391409.2; NM_001007540.4; NP_001007541.2.
DR UCSC; uc003cxp.3; human. [A6H8M9-1]
DR CTD; 389118; -.
DR DisGeNET; 389118; -.
DR GeneCards; CDHR4; -.
DR HGNC; HGNC:34527; CDHR4.
DR HPA; ENSG00000187492; Tissue enriched (fallopian).
DR neXtProt; NX_A6H8M9; -.
DR OpenTargets; ENSG00000187492; -.
DR PharmGKB; PA165696944; -.
DR VEuPathDB; HostDB:ENSG00000187492; -.
DR eggNOG; KOG1219; Eukaryota.
DR GeneTree; ENSGT00940000162824; -.
DR HOGENOM; CLU_382923_0_0_1; -.
DR InParanoid; A6H8M9; -.
DR OMA; APRMEMP; -.
DR OrthoDB; 371149at2759; -.
DR PhylomeDB; A6H8M9; -.
DR TreeFam; TF341878; -.
DR PathwayCommons; A6H8M9; -.
DR BioGRID-ORCS; 389118; 9 hits in 1072 CRISPR screens.
DR GenomeRNAi; 389118; -.
DR Pharos; A6H8M9; Tdark.
DR PRO; PR:A6H8M9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6H8M9; protein.
DR Bgee; ENSG00000187492; Expressed in right uterine tube and 84 other tissues.
DR ExpressionAtlas; A6H8M9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR Pfam; PF00028; Cadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF49313; SSF49313; 4.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..788
FT /note="Cadherin-related family member 4"
FT /id="PRO_0000319973"
FT TOPO_DOM 17..686
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 708..788
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 237..338
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 339..449
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 444..554
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 551..674
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 135
FT /note="A -> GEARGSRQGGGRHGLSRSSLTSTLASWGNDSGARDSHTWGSAVHSAP
FT PRPRTPRSAGKPRTWDGG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031552"
FT VAR_SEQ 136..788
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031553"
FT VARIANT 5
FT /note="R -> K (in dbSNP:rs13072748)"
FT /id="VAR_039109"
SQ SEQUENCE 788 AA; 85827 MW; AAC5C9F6908DBF67 CRC64;
MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP
PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR
DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP
FSINEQGWLQ APSQGLLGQA QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA
QNITIPENLA PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG
TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET APVGTVLNTL
TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL DCDTPGACFQ HAASILVLDG
GQPQMTTEVP VLVMVTPINE FSPACAPRTF RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY
TSGGPTTFAV DRLSGEVHLL GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV
EDVNDHAPEC EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL
QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV PRRASTVATS
THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL LALGWLLGRL LQGLAQLLQA
PSKPAQALLL NSIQGTEGSI EGFLEAPKME MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT
HTGARRWL
