CDHR_PSEAE
ID CDHR_PSEAE Reviewed; 336 AA.
AC Q9HTH5;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=HTH-type transcriptional regulator CdhR;
DE AltName: Full=Carnitine catabolism transcriptional activator;
GN Name=cdhR; OrderedLocusNames=PA5389;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP FUNCTION AS A TRANSCRIPTIONAL REGULATOR, ROLE IN CARNITINE CATABOLISM, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=19406895; DOI=10.1099/mic.0.028787-0;
RA Wargo M.J., Hogan D.A.;
RT "Identification of genes required for Pseudomonas aeruginosa carnitine
RT catabolism.";
RL Microbiology 155:2411-2419(2009).
CC -!- FUNCTION: Induces the transcription of the PA5384-PA5388 operon in
CC response to carnitine. This operon is involved in the degradation of L-
CC carnitine, and allows P.aeruginosa to grow on L-carnitine as the sole
CC source of carbon and nitrogen. {ECO:0000269|PubMed:19406895}.
CC -!- DISRUPTION PHENOTYPE: Cells are incapable of growth on carnitine.
CC {ECO:0000269|PubMed:19406895}.
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DR EMBL; AE004091; AAG08774.1; -; Genomic_DNA.
DR PIR; A82973; A82973.
DR RefSeq; NP_254076.1; NC_002516.2.
DR RefSeq; WP_003114442.1; NZ_QZGE01000031.1.
DR AlphaFoldDB; Q9HTH5; -.
DR SMR; Q9HTH5; -.
DR STRING; 287.DR97_2766; -.
DR PaxDb; Q9HTH5; -.
DR PRIDE; Q9HTH5; -.
DR EnsemblBacteria; AAG08774; AAG08774; PA5389.
DR GeneID; 880749; -.
DR KEGG; pae:PA5389; -.
DR PATRIC; fig|208964.12.peg.5649; -.
DR PseudoCAP; PA5389; -.
DR HOGENOM; CLU_000445_59_0_6; -.
DR InParanoid; Q9HTH5; -.
DR OMA; LYRWHVL; -.
DR PhylomeDB; Q9HTH5; -.
DR BioCyc; PAER208964:G1FZ6-5516-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009896; P:positive regulation of catabolic process; IMP:PseudoCAP.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:PseudoCAP.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52317; SSF52317; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..336
FT /note="HTH-type transcriptional regulator CdhR"
FT /id="PRO_0000417912"
FT DOMAIN 213..311
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 230..251
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 278..301
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT REGION 305..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 37078 MW; 4F8FE077E6605B50 CRC64;
MSQDFWFLLL PGFSVMGFVS AVEPLRVANR FHADLYRWHV LSADGGPVLA SNGMSVNSDG
ALEPLKKGDL LFVVAGFEPL RAVTPALVQW LRKLDRNGVT LGGIDTGSVV LAEAGLLDGR
RATLHWEAID AFQESYPQLS VTQELFEIDG PRITSAGGTA SIDLMLDLIA QAHGPQLAVQ
VSEQFVLGRI RPRQDHQRLQ VATRYGVSNR KLVQVIGEME RHTEPPLTTL ELAERIQVTR
RQLERLFRVH LDDTPSNFYL GLRLDKARQL LRQTDLSVLQ VSLACGFESP SYFSRSYRAR
FAASPSQDRA VLPLKAPAAT PPGAPAGHRT PRAERG
