CDH_CITK8
ID CDH_CITK8 Reviewed; 249 AA.
AC A8AL09;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319}; OrderedLocusNames=CKO_03081;
OS Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=290338;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696;
RG The Citrobacter koseri Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC 3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00319};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC Rule:MF_00319}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00319}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00319}.
CC -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC Rule:MF_00319}.
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DR EMBL; CP000822; ABV14172.1; -; Genomic_DNA.
DR RefSeq; WP_012133879.1; NC_009792.1.
DR AlphaFoldDB; A8AL09; -.
DR SMR; A8AL09; -.
DR STRING; 290338.CKO_03081; -.
DR EnsemblBacteria; ABV14172; ABV14172; CKO_03081.
DR GeneID; 45136883; -.
DR KEGG; cko:CKO_03081; -.
DR HOGENOM; CLU_077117_0_1_6; -.
DR OMA; SPFIMLA; -.
DR OrthoDB; 1854066at2; -.
DR UniPathway; UPA00609; UER00664.
DR Proteomes; UP000008148; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.428.30; -; 1.
DR HAMAP; MF_00319; Cdh; 1.
DR InterPro; IPR003763; CDP-diacylglyc_Pase.
DR InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR InterPro; IPR036265; HIT-like_sf.
DR Pfam; PF02611; CDH; 1.
DR PIRSF; PIRSF001273; CDH; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
DR TIGRFAMs; TIGR00672; cdh; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..249
FT /note="CDP-diacylglycerol pyrophosphatase"
FT /id="PRO_1000019262"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ SEQUENCE 249 AA; 27971 MW; 114B0CAB4D897F5E CRC64;
MKKTGYFLLA VVIVAAVAGI GYWKLAANPN ALRDIVLQQC VPNQLQQQNP APCAEVKPDA
GYVVFKDRNG PLQYLLMPTY RINGTESPLL VEPYTPNFFW LAWQARSFMS QKYGKDIPDS
AISLAINSRS GRTQNHFHIH ISCLRPDVRA QLDDNLAKVS TRWLPLPGGL RGNEYLARRV
TESELAQRSP FMMLAEEVPD AREHMGSYAL AVVRQSDDSF VLLATQRNLL AFNLASAEEI
QDHQCEILQ
