ID   CDH_ECO7I               Reviewed;         251 AA.
AC   B7NU89;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE            EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN   Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319}; OrderedLocusNames=ECIAI39_3078;
OS   Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAI39 / ExPEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00319};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00319}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
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DR   EMBL; CU928164; CAR19197.1; -; Genomic_DNA.
DR   RefSeq; WP_012602489.1; NC_011750.1.
DR   RefSeq; YP_002409008.1; NC_011750.1.
DR   AlphaFoldDB; B7NU89; -.
DR   SMR; B7NU89; -.
DR   STRING; 585057.ECIAI39_3078; -.
DR   EnsemblBacteria; CAR19197; CAR19197; ECIAI39_3078.
DR   KEGG; ect:ECIAI39_3078; -.
DR   PATRIC; fig|585057.6.peg.3190; -.
DR   HOGENOM; CLU_077117_0_1_6; -.
DR   OMA; SPFIMLA; -.
DR   UniPathway; UPA00609; UER00664.
DR   Proteomes; UP000000749; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..251
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_1000119584"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ   SEQUENCE   251 AA;  28369 MW;  FD3C917F912BE128 CRC64;
     MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP
     NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQGRDF MSKKYGQPVP
     DRAVSLAINS RTGRTQNHFH IHISCIRPDV REQLDNNLAN ISSRWLPLPG GLRGHEYLAR
     RVTESELVQR SPFMMLAEEV PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE
     EIQDHQCEIL R