ID   CDH_ECO8A               Reviewed;         251 AA.
AC   B7M6W9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE            EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN   Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319}; OrderedLocusNames=ECIAI1_4123;
OS   Escherichia coli O8 (strain IAI1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585034;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAI1;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00319};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00319}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
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DR   EMBL; CU928160; CAR00894.1; -; Genomic_DNA.
DR   RefSeq; WP_001365904.1; NC_011741.1.
DR   AlphaFoldDB; B7M6W9; -.
DR   SMR; B7M6W9; -.
DR   KEGG; ecr:ECIAI1_4123; -.
DR   HOGENOM; CLU_077117_0_1_6; -.
DR   OMA; SPFIMLA; -.
DR   UniPathway; UPA00609; UER00664.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..251
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_1000119585"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ   SEQUENCE   251 AA;  28414 MW;  8C51AEC36F12C7BF CRC64;
     MKKAGLLFLV MIVIAVVASG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP
     NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP
     DRAVSLAINS RTGRTQNHFH IHISCIRPDV REQLDKNLAN ISSRWLPLPG GLRGHEYLAR
     RVTESELVQR SPFMMLAEEV PEAREHMGSY GLAMVRQSDN SFVLLATQRN LLTLNRASAE
     EIQDHECEIL R