CDH_ECOBW
ID CDH_ECOBW Reviewed; 251 AA.
AC C5A085;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319}; OrderedLocusNames=BWG_3587;
OS Escherichia coli (strain K12 / MC4100 / BW2952).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=595496;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MC4100 / BW2952;
RX PubMed=19376874; DOI=10.1128/jb.00118-09;
RA Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R.,
RA Wang L.;
RT "Genomic sequencing reveals regulatory mutations and recombinational events
RT in the widely used MC4100 lineage of Escherichia coli K-12.";
RL J. Bacteriol. 191:4025-4029(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC 3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00319};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC Rule:MF_00319}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00319}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00319}.
CC -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC Rule:MF_00319}.
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DR EMBL; CP001396; ACR62121.1; -; Genomic_DNA.
DR RefSeq; WP_001326656.1; NC_012759.1.
DR AlphaFoldDB; C5A085; -.
DR SMR; C5A085; -.
DR KEGG; ebw:BWG_3587; -.
DR HOGENOM; CLU_077117_0_1_6; -.
DR OMA; SPFIMLA; -.
DR UniPathway; UPA00609; UER00664.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.428.30; -; 1.
DR HAMAP; MF_00319; Cdh; 1.
DR InterPro; IPR003763; CDP-diacylglyc_Pase.
DR InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR InterPro; IPR036265; HIT-like_sf.
DR Pfam; PF02611; CDH; 1.
DR PIRSF; PIRSF001273; CDH; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
DR TIGRFAMs; TIGR00672; cdh; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Transmembrane; Transmembrane helix.
FT CHAIN 1..251
FT /note="CDP-diacylglycerol pyrophosphatase"
FT /id="PRO_1000205113"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ SEQUENCE 251 AA; 28451 MW; F2E704FD5E164779 CRC64;
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP
NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP
DRAVSLAINS RTGRTQNHFH IHISCIRPDV RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR
RVTESELVQR SPFMMLAEEV PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE
EIQDHQCEIL R
