CDH_ECOLI
ID CDH_ECOLI Reviewed; 251 AA.
AC P06282; Q2M8L4;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE EC=3.6.1.26;
DE AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE AltName: Full=CDP-diglyceride hydrolase;
GN Name=cdh; OrderedLocusNames=b3918, JW3889;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2995360; DOI=10.1016/s0021-9258(17)38990-1;
RA Icho T., Bulawa C.E., Raetz C.R.H.;
RT "Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase
RT of Escherichia coli.";
RL J. Biol. Chem. 260:12092-12098(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3158524; DOI=10.1111/j.1432-1033.1985.tb08934.x;
RA Hellinga H.W., Evans P.R.;
RT "Nucleotide sequence and high-level expression of the major Escherichia
RT coli phosphofructokinase.";
RL Eur. J. Biochem. 149:363-373(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8346018; DOI=10.1093/nar/21.15.3391;
RA Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome. III. DNA sequence of the region
RT from 87.2 to 89.2 minutes.";
RL Nucleic Acids Res. 21:3391-3398(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC 3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:60377; EC=3.6.1.26;
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC phosphatidate from CDP-diacylglycerol: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA26358.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M11331; AAA23543.1; -; Genomic_DNA.
DR EMBL; X02519; CAA26358.1; ALT_FRAME; Genomic_DNA.
DR EMBL; L19201; AAB03050.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76900.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77392.1; -; Genomic_DNA.
DR PIR; A01019; PSECCD.
DR RefSeq; NP_418353.1; NC_000913.3.
DR RefSeq; WP_001326656.1; NZ_SSZK01000014.1.
DR AlphaFoldDB; P06282; -.
DR SMR; P06282; -.
DR BioGRID; 4261218; 158.
DR IntAct; P06282; 3.
DR STRING; 511145.b3918; -.
DR jPOST; P06282; -.
DR PaxDb; P06282; -.
DR PRIDE; P06282; -.
DR EnsemblBacteria; AAC76900; AAC76900; b3918.
DR EnsemblBacteria; BAE77392; BAE77392; BAE77392.
DR GeneID; 948410; -.
DR KEGG; ecj:JW3889; -.
DR KEGG; eco:b3918; -.
DR PATRIC; fig|1411691.4.peg.2787; -.
DR EchoBASE; EB0136; -.
DR eggNOG; COG2134; Bacteria.
DR HOGENOM; CLU_077117_0_1_6; -.
DR InParanoid; P06282; -.
DR OMA; SPFIMLA; -.
DR PhylomeDB; P06282; -.
DR BioCyc; EcoCyc:CDPDIGLYPYPHOSPHA-MON; -.
DR BioCyc; MetaCyc:CDPDIGLYPYPHOSPHA-MON; -.
DR UniPathway; UPA00609; UER00664.
DR PRO; PR:P06282; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IDA:EcoCyc.
DR GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IMP:EcoCyc.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.428.30; -; 1.
DR HAMAP; MF_00319; Cdh; 1.
DR InterPro; IPR003763; CDP-diacylglyc_Pase.
DR InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR InterPro; IPR036265; HIT-like_sf.
DR Pfam; PF02611; CDH; 1.
DR PIRSF; PIRSF001273; CDH; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
DR TIGRFAMs; TIGR00672; cdh; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..251
FT /note="CDP-diacylglycerol pyrophosphatase"
FT /id="PRO_0000198573"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 251 AA; 28451 MW; F2E704FD5E164779 CRC64;
MKKAGLLFLV MIVIAVVAAG IGYWKLTGEE SDTLRKIVLE ECLPNQQQNQ NPSPCAEVKP
NAGYVVLKDL NGPLQYLLMP TYRINGTESP LLTDPSTPNF FWLAWQARDF MSKKYGQPVP
DRAVSLAINS RTGRTQNHFH IHISCIRPDV RKQLDNNLAN ISSRWLPLPG GLRGHEYLAR
RVTESELVQR SPFMMLAEEV PEAREHMGRY GLAMVRQSDN SFVLLATQRN LLTLNRASAE
EIQDHQCEIL R
