ID   CDH_ENTCL               Reviewed;         247 AA.
AC   Q9Z6C1;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2001, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE            EC=3.6.1.26;
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE   AltName: Full=CDP-diglyceride hydrolase;
GN   Name=cdh;
OS   Enterobacter cloacae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A-11 / 501R3;
RX   PubMed=10347036; DOI=10.1128/aem.65.6.2513-2519.1999;
RA   Roberts D.P., Dery P.D., Yucel I., Buyer J., Holtman M.A., Kobayashi D.Y.;
RT   "Role of pfkA and general carbohydrate catabolism in seed colonization by
RT   Enterobacter cloacae.";
RL   Appl. Environ. Microbiol. 65:2513-2519(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26;
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD16181.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF098509; AAD16181.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q9Z6C1; -.
DR   SMR; Q9Z6C1; -.
DR   STRING; 1399774.JDWH01000014_gene3523; -.
DR   eggNOG; COG2134; Bacteria.
DR   UniPathway; UPA00609; UER00664.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..247
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_0000198576"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  27718 MW;  C73E28CC9A36E4F7 CRC64;
     MKKIILLLLI VIALAAGGVY WMKAGNPNAL RHIVLDQCVP NQIQNRNPAP CAQVKTDAGY
     VVFKDRNGPL QYLLMPTYRI NGTESPLLTE AHTPNFFWLA WQSRSFMTLK HGSEVPDSAI
     SLTINSPTGR TQNHFHIHIS CLRPDVREKL NAAQGEISTQ WLPLPGGLEG HEYLARRVTE
     NELVQRSPFM MLAEELPEAR DHMGRFALAM AQQSDGSFVL LATERNLLTL NRASAEELQD
     HQCTILK