CDH_HELPJ
ID CDH_HELPJ Reviewed; 244 AA.
AC Q9ZKX9;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE EC=3.6.1.26;
DE AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE AltName: Full=CDP-diglyceride hydrolase;
GN Name=cdh; OrderedLocusNames=jhp_0805;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC 3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:60377; EC=3.6.1.26;
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC phosphatidate from CDP-diacylglycerol: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
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DR EMBL; AE001439; AAD06387.1; -; Genomic_DNA.
DR PIR; B71885; B71885.
DR AlphaFoldDB; Q9ZKX9; -.
DR SMR; Q9ZKX9; -.
DR STRING; 85963.jhp_0805; -.
DR EnsemblBacteria; AAD06387; AAD06387; jhp_0805.
DR KEGG; hpj:jhp_0805; -.
DR PATRIC; fig|85963.30.peg.167; -.
DR eggNOG; COG2134; Bacteria.
DR OMA; SPFIMLA; -.
DR UniPathway; UPA00609; UER00664.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.428.30; -; 1.
DR HAMAP; MF_00319; Cdh; 1.
DR InterPro; IPR003763; CDP-diacylglyc_Pase.
DR InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR InterPro; IPR036265; HIT-like_sf.
DR Pfam; PF02611; CDH; 1.
DR PIRSF; PIRSF001273; CDH; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
DR TIGRFAMs; TIGR00672; cdh; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="CDP-diacylglycerol pyrophosphatase"
FT /id="PRO_0000198578"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 27450 MW; CC612DA76EC2E9F6 CRC64;
MKKAGFLFLA AMAIIVVSLN AKDPNVLRKI VFEKCLPNYE KNQNPSPCIE VKPDAGYVVL
KDINGPLQYL LMPTTHISGI ENPLLLDPST PNFFYLSWQA RDFMSKKYGK PIPDYAISLT
INSKKGRSQN HFHIHISCIS LDVRKQLDNN LKNINSRWSP LSGGLNGHKY LARRVTESEL
AQKSPFVMLA KEVPNAHKRM GDYGLAVVQQ SDNSFVLLAT QFNPLTLNRA SAEEIQDHEC
AILR
