ID   CDH_HELPY               Reviewed;         244 AA.
AC   Q48248;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE            EC=3.6.1.26;
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE   AltName: Full=CDP-diglyceride hydrolase;
GN   Name=cdh; OrderedLocusNames=HP_0871;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-244.
RC   STRAIN=951, and DSM 4867 / CCUG 17874 / NCTC 11638;
RX   PubMed=7891557; DOI=10.1111/j.1365-2958.1994.tb01307.x;
RA   O'Toole P.W., Kostrzynska M., Trust T.J.;
RT   "Non-motile mutants of Helicobacter pylori and Helicobacter mustelae
RT   defective in flagellar hook production.";
RL   Mol. Microbiol. 14:691-703(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26;
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000511; AAD07921.1; -; Genomic_DNA.
DR   EMBL; U09549; AAA92802.1; -; Genomic_DNA.
DR   PIR; G64628; G64628.
DR   RefSeq; NP_207665.1; NC_000915.1.
DR   RefSeq; WP_000708956.1; NC_018939.1.
DR   AlphaFoldDB; Q48248; -.
DR   SMR; Q48248; -.
DR   STRING; 85962.C694_04460; -.
DR   PaxDb; Q48248; -.
DR   EnsemblBacteria; AAD07921; AAD07921; HP_0871.
DR   KEGG; hpy:HP_0871; -.
DR   PATRIC; fig|85962.47.peg.926; -.
DR   eggNOG; COG2134; Bacteria.
DR   OMA; SPFIMLA; -.
DR   PhylomeDB; Q48248; -.
DR   UniPathway; UPA00609; UER00664.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..244
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_0000198577"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   244 AA;  27516 MW;  0930D0B9B1377C1A CRC64;
     MKKAGFLFLA VMAIVVMSLN AKDPNVLRKI VFEKCLPNYE KNQNPSPCIE VKPDAGYVVL
     KDINGPLQYL LMPTTHISGI ESPLLLDPST PNFFYLSWQA RDFMSKKYGQ PIPDYAISLT
     INSSKGRSQN HFHIHISCIS LEARKQLDNN LKKINSRWSP LPGGLNGHKY LARRVTESEL
     VQKSPFVMLN KEVPNAYKRM GDYGLAVVQQ SDNSFVLLAT QFNPLTLNRA SAEEIQDHEC
     AILH