ID   CDH_MYCBT               Reviewed;         260 AA.
AC   C1AQK4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_00319};
DE            EC=3.6.1.26 {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
DE   AltName: Full=CDP-diglyceride hydrolase {ECO:0000255|HAMAP-Rule:MF_00319};
GN   Name=cdh {ECO:0000255|HAMAP-Rule:MF_00319}; OrderedLocusNames=JTY_2299;
OS   Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=561275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Tokyo 172 / ATCC 35737 / TMC 1019;
RX   PubMed=19200449; DOI=10.1016/j.vaccine.2009.01.034;
RA   Seki M., Honda I., Fujita I., Yano I., Yamamoto S., Koyama A.;
RT   "Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-
RT   Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.";
RL   Vaccine 27:1710-1716(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00319};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00319};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00319}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000255|HAMAP-
CC       Rule:MF_00319}.
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DR   EMBL; AP010918; BAH26583.1; -; Genomic_DNA.
DR   RefSeq; WP_003411717.1; NZ_CP014566.1.
DR   AlphaFoldDB; C1AQK4; -.
DR   SMR; C1AQK4; -.
DR   GeneID; 45426268; -.
DR   KEGG; mbt:JTY_2299; -.
DR   HOGENOM; CLU_077117_1_0_11; -.
DR   OMA; SPFIMLA; -.
DR   UniPathway; UPA00609; UER00664.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..260
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_1000133035"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00319"
SQ   SEQUENCE   260 AA;  28608 MW;  D2884BE3B6F1489D CRC64;
     MPKSRRAVSL SVLIGAVIAA LAGALIAVTV PARPNRPEAD REALWKIVHD RCEFGYRRTG
     AYAPCTFVDE QSGTALYKAD FDPYQFLLIP LARITGIEDP ALRESAGRNY LYDAWAARFL
     VTARLNNSLP ESDVVLTINP KNARTQDQLH IHISCSSPTT SAALRNVDTS EYVGWKQLPI
     DLGGRRFQGL AVDTKAFESR NLFRDIYLKV TADGKKMENA SIAVANVAQD QFLLLLAEGT
     EDQPVAAETL QDHDCSITKS