CDH_MYCLE
ID CDH_MYCLE Reviewed; 268 AA.
AC Q9CC08;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Probable CDP-diacylglycerol pyrophosphatase;
DE EC=3.6.1.26;
DE AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE AltName: Full=CDP-diglyceride hydrolase;
GN Name=cdh; OrderedLocusNames=ML1417;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC 3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:60377; EC=3.6.1.26;
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC phosphatidate from CDP-diacylglycerol: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
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DR EMBL; AL583922; CAC30368.1; -; Genomic_DNA.
DR PIR; C87086; C87086.
DR RefSeq; NP_302007.1; NC_002677.1.
DR RefSeq; WP_010908328.1; NC_002677.1.
DR AlphaFoldDB; Q9CC08; -.
DR SMR; Q9CC08; -.
DR STRING; 272631.ML1417; -.
DR EnsemblBacteria; CAC30368; CAC30368; CAC30368.
DR KEGG; mle:ML1417; -.
DR PATRIC; fig|272631.5.peg.2627; -.
DR Leproma; ML1417; -.
DR eggNOG; COG2134; Bacteria.
DR HOGENOM; CLU_077117_0_0_11; -.
DR OMA; SPFIMLA; -.
DR UniPathway; UPA00609; UER00664.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.428.30; -; 1.
DR HAMAP; MF_00319; Cdh; 1.
DR InterPro; IPR003763; CDP-diacylglyc_Pase.
DR InterPro; IPR036265; HIT-like_sf.
DR Pfam; PF02611; CDH; 1.
DR PIRSF; PIRSF001273; CDH; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..268
FT /note="Probable CDP-diacylglycerol pyrophosphatase"
FT /id="PRO_0000198579"
FT TRANSMEM 5..23
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 268 AA; 29481 MW; 54525B3DB4E2FBAC CRC64;
MRRSIILVSV SVAIAMLTGA SIAEAEPMPP NNPSAATRDA LWKIVHDRCE LGYQHTGAYA
PCTLVDEQAG TALFKANYDP NQYLLLPLAR VTGIEDPALQ ELASPNYLYN AWAARGFVSS
RLNNSLPEPD IFLAINPKNA RTQDQLHIHI SCVSPTTAEI LKQVNWAEYV GWKPLPVTLQ
DHTYQALAVN RSTFESKSLF RDIQTKVTAD GNTMDHASVA VANIAPDQFL LLVAEGTEDQ
AIAAEELQDH NCSIAKRLTG QLDMETRR
