ID   CDH_MYCTU               Reviewed;         260 AA.
AC   P9WPG9; L0TC27; P63751; Q50676;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Probable CDP-diacylglycerol pyrophosphatase;
DE            EC=3.6.1.26;
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE   AltName: Full=CDP-diglyceride hydrolase;
GN   Name=cdh; OrderedLocusNames=Rv2289; ORFNames=MTCY339.21c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26;
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45071.1; -; Genomic_DNA.
DR   PIR; E70732; E70732.
DR   RefSeq; NP_216805.1; NC_000962.3.
DR   RefSeq; WP_003411717.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WPG9; -.
DR   SMR; P9WPG9; -.
DR   STRING; 83332.Rv2289; -.
DR   PaxDb; P9WPG9; -.
DR   DNASU; 887342; -.
DR   GeneID; 45426268; -.
DR   GeneID; 887342; -.
DR   KEGG; mtu:Rv2289; -.
DR   TubercuList; Rv2289; -.
DR   eggNOG; COG2134; Bacteria.
DR   OMA; SPFIMLA; -.
DR   PhylomeDB; P9WPG9; -.
DR   UniPathway; UPA00609; UER00664.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.428.30; -; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR036265; HIT-like_sf.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..260
FT                   /note="Probable CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_0000198580"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  28608 MW;  D2884BE3B6F1489D CRC64;
     MPKSRRAVSL SVLIGAVIAA LAGALIAVTV PARPNRPEAD REALWKIVHD RCEFGYRRTG
     AYAPCTFVDE QSGTALYKAD FDPYQFLLIP LARITGIEDP ALRESAGRNY LYDAWAARFL
     VTARLNNSLP ESDVVLTINP KNARTQDQLH IHISCSSPTT SAALRNVDTS EYVGWKQLPI
     DLGGRRFQGL AVDTKAFESR NLFRDIYLKV TADGKKMENA SIAVANVAQD QFLLLLAEGT
     EDQPVAAETL QDHDCSITKS